Chemical Identity and Structure

1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid belongs to the class of N-arylimidazole carboxylic acids. Its molecular framework consists of an imidazole ring bearing a 4-fluorophenyl substituent at the N1 nitrogen and a carboxylic acid group at the C4 position. The electron-withdrawing fluorine atom on the phenyl ring modulates the electronic character of the aromatic system, influencing both reactivity and potential binding interactions with biological targets. The carboxylic acid moiety provides a versatile handle for further chemical elaboration, including amide bond formation, esterification, and coordination chemistry. This compound is catalogued by Aladdin Scientific under SKU H728937.

Research Applications

This compound finds utility across several areas of chemical research:

• Medicinal Chemistry Building Block: The N-arylimidazole-carboxylic acid scaffold is frequently employed in the synthesis of pharmacologically relevant compounds. The carboxylic acid group allows direct coupling with amines to generate amide derivatives, which are common pharmacophores in drug discovery programs.
• Heterocyclic Synthesis: The compound can serve as a precursor or intermediate in constructing more complex heterocyclic frameworks via condensation, cyclization, or cross-coupling strategies.
• Fluorine-Containing Compound Library: Fluorine substitution is a widely exploited strategy in medicinal and agrochemical research to enhance metabolic stability, lipophilicity, and membrane permeability of lead compounds. This reagent contributes to the construction of fluorinated compound libraries.
• Coordination Chemistry: The imidazole nitrogen and carboxylate functionality together provide potential coordination sites for metal ions, making this compound of interest in the design of metal-organic ligands.

Handling, Storage, and Safety Guidelines

Although specific hazard data for this compound should be confirmed in the official Safety Data Sheet (SDS) provided by Aladdin Scientific, the following general guidelines apply to N-aryl imidazole carboxylic acid reagents:

• Personal Protective Equipment (PPE): Wear appropriate gloves (nitrile recommended), safety goggles, and a lab coat when handling the compound. Use a chemical fume hood if generating dust or aerosols.
• Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area, away from incompatible materials such as strong oxidising agents and strong bases. Refer to the product SDS for temperature-specific storage recommendations.
• Disposal: Dispose of waste in accordance with applicable local, regional, and national regulations governing chemical waste. Do not pour down the drain without confirming local regulatory compliance.
• First Aid: In case of skin or eye contact, flush immediately with copious amounts of water and seek medical attention if irritation persists. Consult the SDS for complete first-aid measures.

Always consult the current Aladdin Scientific SDS for authoritative safety information before use.

Ordering and Specifications

1-(4-Fluorophenyl)-1H-imidazole-4-carboxylic acid is available from Aladdin Scientific under SKU H728937. When placing an order or requesting a quotation, researchers and procurement teams should note the following:

• Product SKU: H728937
• Purity and Grade: Confirm the specific purity grade and analytical data (e.g., HPLC purity, NMR confirmation) with Aladdin Scientific at the time of ordering, as these may vary by lot.
• Pack Sizes: Available pack sizes should be confirmed with Aladdin Scientific sales or via the product page, as offerings may be updated.
• Documentation: Certificate of Analysis (CoA) and SDS are available upon request or via the Aladdin Scientific website.
• Lead Time: Contact Aladdin Scientific for current stock availability and estimated delivery timelines.