1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione: FAQs & Specs
1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione: FAQs & Specs
1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione is a methylated isatin analogue bearing N-methyl and 5-methyl substituents on the indoline-2,3-dione core, making it a versatile building block for synthetic and medicinal chemistry research.
- Chemical Name
- 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione
- SKU / Catalog Number
- D708700
- Compound Class
- N-substituted isatin derivative (indole-2,3-dione)
- Key Structural Features
- N-methyl group at position 1; methyl substituent at position 5; diketone functionality at C-2 and C-3
- Supplier
- Aladdin Scientific
- Recommended Storage
- Store in a cool, dry place away from light and moisture; consult SDS for full details
What Is 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione?
1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione is a synthetic organic compound belonging to the isatin (indole-2,3-dione) family of heterocycles. It differs from the parent isatin by the presence of a methyl group on the ring nitrogen (N-1 position) and a second methyl substituent at the 5-position of the benzene ring. These substitutions modulate electronic and steric properties relative to unsubstituted isatin, making this compound a useful intermediate and building block in organic synthesis, medicinal chemistry, and materials research.
The compound features a bicyclic scaffold comprising a benzene ring fused to a five-membered diketone-containing ring. The adjacent carbonyl groups at C-2 and C-3 confer electrophilic character and enable diverse condensation, cyclization, and nucleophilic addition reactions that are well established in the isatin literature.
Physical and Chemical Properties
As an N-methyl-5-methylisatin derivative, this compound is expected to be a solid at room temperature with moderate lipophilicity, consistent with other ring-methylated isatin analogues. The presence of two carbonyl groups results in characteristic infrared absorption bands in the 1700–1750 cm⁻¹ region. Solubility is anticipated in common polar organic solvents such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF), and ethanol, with limited solubility in water.
For confirmed physical constants including melting point, molecular weight, purity, and spectroscopic data, researchers should consult the Certificate of Analysis (CoA) provided with the specific lot of product D708700 from Aladdin Scientific.
Handling, Safety, and Storage
Researchers should treat 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione with standard laboratory precautions applicable to reactive organic intermediates. Personal protective equipment (PPE) including gloves, safety glasses, and a laboratory coat should be worn. Work should be performed in a well-ventilated area or under a fume hood to minimise inhalation of dust or vapours.
For storage, keep the compound tightly sealed in a cool, dry location away from direct light, heat sources, and incompatible materials (e.g., strong oxidising agents, strong bases). Always consult the Safety Data Sheet (SDS) for this product before first use. Dispose of waste in accordance with local environmental regulations.
Ordering and Availability from Aladdin Scientific
1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione is available from Aladdin Scientific under catalog number D708700. To place an order, customers can visit the Aladdin Scientific website, locate the product by SKU or name, select the desired pack size and quantity, and proceed through the standard checkout process.
For bulk quantities, custom pack sizes, or questions regarding pricing and availability, please contact Aladdin Scientific's customer service team directly. Registered account holders can also track orders, download CoAs and SDS documents, and manage invoices through the online account portal.
Frequently asked questions
What is the catalog number for 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione at Aladdin Scientific?
The catalog number (SKU) for 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione at Aladdin Scientific is D708700. You can search this SKU directly on the Aladdin Scientific website to view current pricing, pack sizes, and availability.
What solvents are recommended for dissolving 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione?
Based on general solubility trends for N-alkyl isatin derivatives, polar aprotic solvents such as DMSO and DMF, as well as ethanol, are expected to dissolve this compound effectively. Solubility in water is expected to be low. Researchers should verify solubility experimentally and consult the product CoA for confirmed solubility data.
How should 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione be stored to maintain stability?
The compound should be stored tightly sealed in a cool, dry location away from light, moisture, and heat. These conditions are standard for isatin-class diketone compounds, which can be susceptible to moisture and photodegradation. Always refer to the product SDS and CoA for lot-specific storage recommendations.
What types of chemical reactions is 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione suitable for?
Like other isatin derivatives, this compound is well-suited for condensation reactions (e.g., Knoevenagel condensation), nucleophilic addition at the C-3 carbonyl, and cycloaddition reactions, all of which are widely reported for the isatin scaffold in the synthesis of heterocyclic libraries. The N-methyl and 5-methyl groups modulate reactivity and selectivity relative to unsubstituted isatin.
How can I obtain the Certificate of Analysis or Safety Data Sheet for D708700?
The Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for catalog number D708700 can be downloaded from the Aladdin Scientific website by searching the product page. Registered users can also access these documents through their online account portal. If documents are not readily available online, please contact Aladdin Scientific customer service with your lot number.
References
- General reference: Isatin and its derivatives — a pharmacological review. Substantive literature on isatin chemistry and biological activity. Specific citation details to be confirmed by editorial review.
- Aladdin Scientific product page for D708700: 1,5-Dimethyl-2,3-dihydro-1h-indole-2,3-dione. Aladdin Scientific, catalog number D708700.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
危险品化学品经营许可证（带存储）