What Is 1-(Aminomethyl)-N,N-dimethylcyclobutanamine?

1-(Aminomethyl)-N,N-dimethylcyclobutanamine is a small, bifunctional organic compound built on a strained cyclobutane scaffold. The molecule carries two distinct nitrogen-containing moieties: a primary amine presented as an aminomethyl (–CH₂NH₂) pendant group, and a tertiary dimethylamino [–N(CH₃)₂] group attached directly to the quaternary carbon of the ring. This combination of functionality on a conformationally restricted ring system makes the compound attractive as a synthetic intermediate and fragment for structure–activity relationship (SAR) studies in drug discovery programs. The cyclobutane ring confers three-dimensional character and metabolic stability compared with acyclic analogs, properties increasingly valued in modern medicinal chemistry.

Typical Uses and Applications

Researchers employ 1-(Aminomethyl)-N,N-dimethylcyclobutanamine primarily as a building block in multi-step organic synthesis. The free primary amine can participate in acylation, reductive amination, sulfonylation, and coupling reactions, while the tertiary amine can act as a basic handle or be exploited for further quaternization. Key application areas include:

• Medicinal chemistry: Incorporation of a rigidified diamine motif into drug candidates to improve selectivity and reduce conformational entropy penalties upon receptor binding.
• Fragment-based drug discovery (FBDD): The compact, polar nature of the molecule makes it suitable as a fragment hit or for elaboration into larger lead compounds.
• Peptide and peptidomimetic synthesis: The aminomethyl group can serve as a non-natural amino acid equivalent when appropriately protected.
• Material science: Bifunctional amines are used as cross-linkers or curing agents in polymer chemistry contexts.

Always consult peer-reviewed literature and validated protocols before using this compound in novel synthetic routes.

Handling, Safety, and Storage

As with most low-molecular-weight aliphatic amines, 1-(Aminomethyl)-N,N-dimethylcyclobutanamine should be handled with appropriate precautions:

• Personal protective equipment (PPE): Wear nitrile gloves, safety glasses, and a lab coat. Work in a well-ventilated fume hood to avoid inhalation of vapors.
• Storage: Store tightly sealed under an inert atmosphere (nitrogen or argon) in a cool, dry location away from oxidizers, strong acids, and moisture. Specific temperature recommendations should be confirmed on the product SDS provided by Aladdin Scientific.
• Stability: Primary amines can be prone to oxidation and carbonate formation upon exposure to CO₂ and moisture; keep containers closed when not in use.
• Waste disposal: Dispose of in accordance with local, regional, and national regulations for amine-containing chemical waste.

Always download and review the current Safety Data Sheet (SDS) for SKU N724879 from the Aladdin Scientific website before first use.

Ordering and Availability at Aladdin Scientific

1-(Aminomethyl)-N,N-dimethylcyclobutanamine is catalogued under SKU N724879 at Aladdin Scientific. To place an order or request a quotation:

1. Visit the Aladdin Scientific website and search by product name or SKU N724879.
2. Select the required pack size and purity grade.
3. Add to cart and proceed through the standard checkout process, or contact our sales team for bulk pricing and custom pack sizes.
4. Registered account holders can track orders, download invoices, and access certificates of analysis (CoA) directly from their account dashboard.

For institutional purchase orders, framework agreements, or questions about lead times, contact Aladdin Scientific customer service. Expedited shipping options may be available depending on your region; please confirm at time of order.

Purity, Specifications, and Quality Assurance

Aladdin Scientific is committed to providing research-grade reagents with documented quality. For SKU N724879, researchers should note:

• Purity: Exact purity specification should be confirmed by reviewing the current Certificate of Analysis (CoA) available on the product page, as lot-to-lot specifications may vary.
• Analytical methods: Purity is typically assessed by techniques such as GC, HPLC, or NMR; the specific methods used are stated on the CoA.
• Regulatory documentation: SDS, CoA, and, where applicable, REACH documentation are available for download from the Aladdin Scientific website.
• Custom purity grades: For applications requiring higher purity or special certification, contact Aladdin Scientific technical support to discuss options.

If you receive a product that does not meet the stated specification, please contact Aladdin Scientific customer service to initiate a return or replacement in accordance with the returns and refunds policy.