What Is 1'-Benzyl-7-methoxyspiro[3H-chromene-2,4'-piperidine]-4-one?

1'-Benzyl-7-methoxyspiro[3H-chromene-2,4'-piperidine]-4-one (SKU: B726068) is a synthetic spirocyclic organic compound that combines a 4H-chromen-4-one (chromone/chromenone) moiety with a piperidine ring joined through a spiro carbon at position 2 of the chromene and position 4 of the piperidine. A methoxy group at C-7 of the chromene ring and an N-benzyl group on the piperidine nitrogen further define its structure and physicochemical profile.

Spiro compounds of this type are of broad interest in drug discovery because the spiro junction introduces three-dimensional character and restricted conformational flexibility, properties that can improve selectivity when engaging biological targets. The chromenone and piperidine subunits are individually well-represented in bioactive natural products and approved pharmaceuticals, making their combination in a single spiro scaffold particularly attractive as a medicinal chemistry starting point.

Physical and Chemical Properties

As a spirocyclic compound incorporating both a lactone-type carbonyl (chromenone C-4 ketone) and a tertiary amine (N-benzylpiperidine), 1'-Benzyl-7-methoxyspiro[3H-chromene-2,4'-piperidine]-4-one is expected to present moderate lipophilicity influenced by the aromatic benzyl and methoxyphenyl groups, balanced against the basic piperidine nitrogen. These features situate the molecule within ranges commonly explored in lead-like chemical space.

The compound is typically handled as a solid. Solubility in polar aprotic solvents such as DMSO and DMF is generally anticipated for compounds of this structural class, facilitating preparation of stock solutions for biological assays. Specific melting point, exact molecular weight, purity specification, and confirmed spectral data (NMR, MS) are provided on the Aladdin Scientific product page and Certificate of Analysis (CoA) supplied with each lot.

Note: Precise physicochemical values (MW, mp, logP, purity) should be verified against the current product CoA and Safety Data Sheet (SDS) available from Aladdin Scientific, as batch-specific data may vary.

Storage, Handling, and Safety

General best practices for research-grade spiro heterocyclic compounds apply to 1'-Benzyl-7-methoxyspiro[3H-chromene-2,4'-piperidine]-4-one. The compound should be stored in a tightly sealed container, protected from light and moisture, and kept at the temperature recommended on the product label (commonly 2–8 °C or room temperature under desiccation, depending on lot-specific stability data). Always consult the SDS before use.

When handling, use appropriate personal protective equipment (PPE) including lab coat, chemical-resistant gloves, and eye protection. Work in a well-ventilated area or fume hood. Avoid inhalation of dust or aerosols. The compound has not been fully characterized for toxicological endpoints; treat it as a potentially hazardous chemical until complete hazard data are available. Dispose of waste in accordance with local institutional and regulatory guidelines.

Ordering and Availability from Aladdin Scientific

1'-Benzyl-7-methoxyspiro[3H-chromene-2,4'-piperidine]-4-one is available from Aladdin Scientific under SKU B726068. To place an order, visit the Aladdin Scientific website, search by product name or SKU, and add the desired quantity to your cart. Registered account holders can access order history, download invoices, and request quotes for bulk quantities through the account dashboard.

For questions about pricing, available pack sizes, custom synthesis, bulk orders, or lead times, contact Aladdin Scientific customer service directly via the website contact form or by telephone. Export orders may be subject to additional documentation requirements and shipping restrictions depending on destination country regulations.