What Is 1-(Difluoromethyl)cyclopropane-1-carboxylic Acid?

1-(Difluoromethyl)cyclopropane-1-carboxylic acid (Aladdin SKU: C628235) is a specialty fluorinated organic compound that combines two structurally valuable motifs: a strained cyclopropane ring and a difluoromethyl (–CHF₂) group, both attached to the same quaternary carbon that also bears a carboxylic acid functionality.

The cyclopropane ring imparts conformational rigidity and can act as a bioisostere for a range of planar or sp²-hybridised groups, while the difluoromethyl group is well recognised in medicinal chemistry for modulating lipophilicity, hydrogen-bond donor capacity, and metabolic stability of drug molecules. The free carboxylic acid provides a versatile handle for amide coupling, esterification, and other downstream transformations, making this compound a valuable building block in drug discovery programmes and fluorine chemistry research.

Key Chemical Properties and Handling

As a carboxylic acid, this compound is mildly acidic and should be handled with standard laboratory precautions: wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work in a well-ventilated fume hood to minimise inhalation exposure to dust or vapours.

The difluoromethyl group is chemically stable under most standard synthetic conditions, but the compound should be kept away from strong bases and strong oxidising agents. Because cyclopropane rings can be susceptible to ring-opening under harsh acidic or reductive conditions, reaction conditions should be chosen carefully when these functional group transformations are planned.

For specific melting point, boiling point, molecular weight, molecular formula, purity specification, and spectral data, please refer to the product certificate of analysis (CoA) and safety data sheet (SDS) available on the Aladdin Scientific product page for C628235, or contact our technical support team.

Applications in Medicinal Chemistry and Synthesis

This compound is primarily employed as a building block in the synthesis of biologically active molecules, particularly in lead optimisation stages of drug discovery. The combination of the cyclopropane ring and the difluoromethyl group offers researchers a powerful tool to fine-tune the physicochemical and ADMET properties of candidate compounds without substantially increasing molecular weight.

Typical synthetic transformations utilising the carboxylic acid functionality include:

• Amide bond formation — coupling with amines using standard reagents (e.g., HATU, EDC/HOBt, T3P) to produce amide-containing drug candidates.
• Esterification — preparation of ester prodrugs or synthetic intermediates.
• Reduction — conversion to the corresponding alcohol for further elaboration.
• Decarboxylation and radical reactions — in appropriate contexts, carboxylic acids can serve as radical precursors.

The difluoromethyl group itself is generally inert under standard coupling conditions, making this building block straightforward to incorporate into multi-step synthetic routes.

Storage, Stability, and Quality

To preserve compound integrity, store 1-(difluoromethyl)cyclopropane-1-carboxylic acid (C628235) according to the conditions specified in the product SDS and CoA. General best practices for small-molecule carboxylic acid building blocks include storage in a tightly sealed container in a cool, dry environment, away from light, moisture, and incompatible materials such as strong bases or oxidisers.

Aladdin Scientific conducts quality control testing on all reagent products. The purity specification and analytical data (e.g., NMR, HPLC, GC) for each lot are documented in the CoA, which is available upon request or via the product page. If you have questions about a specific lot's quality data, please contact Aladdin Scientific customer service with your order or lot number.

If the compound shows unexpected colour change, solidification, or other signs of degradation upon receipt, contact Aladdin Scientific immediately to arrange an inspection or replacement under our returns and refunds policy.

How to Order and Technical Support

1-(Difluoromethyl)cyclopropane-1-carboxylic acid is available from Aladdin Scientific under SKU C628235. To place an order, visit the Aladdin Scientific website, search for the SKU or product name, select the required quantity and pack size, and proceed through the standard checkout process. Bulk quantities and custom pack sizes may be available — please contact our sales team for a quotation.

For technical questions regarding the compound's properties, suitable reaction conditions, analytical characterisation, or compatibility with specific assay formats, please reach out to Aladdin Scientific's technical support team via the contact details on our website. Our team can also assist with providing CoA documents, SDS files, and structural data.

For order status, shipping enquiries, payment questions, or returns, please contact Aladdin Scientific customer service directly, referencing your order number.