1-Ethyl-3-methyl-1H-pyrazol-5-amine: Properties & Lab FAQ
1-Ethyl-3-methyl-1H-pyrazol-5-amine: Properties & Lab FAQ
1-Ethyl-3-methyl-1H-pyrazol-5-amine is a versatile aminopyrazole heterocyclic building block widely used in medicinal chemistry and synthetic research for the construction of pharmacologically relevant scaffolds.
- IUPAC Name
- 1-Ethyl-3-methyl-1H-pyrazol-5-amine
- Aladdin SKU
- E700645
- Molecular Formula
- C6H11N3
- Molecular Weight
- 125.17 g/mol
- Compound Class
- Aminopyrazole heterocycle
- Primary Use
- Synthetic intermediate and building block in medicinal chemistry
Chemical Identity and Structure
1-Ethyl-3-methyl-1H-pyrazol-5-amine belongs to the aminopyrazole family of five-membered nitrogen-containing heterocycles. Its structure features an ethyl substituent on N-1, a methyl group at C-3, and a primary amine (–NH2) at C-5. This arrangement confers bifunctional reactivity: the ring nitrogens and the exocyclic amine each provide distinct handles for further derivatization.
The molecular formula is C6H11N3 with a molecular weight of approximately 125.17 g/mol. The compound is catalogued under Aladdin Scientific SKU E700645.
Physicochemical Properties and Solubility
As a small, polar heterocyclic amine, 1-Ethyl-3-methyl-1H-pyrazol-5-amine is expected to show appreciable solubility in polar protic solvents such as water, methanol, and ethanol, as well as in polar aprotic solvents including DMSO and DMF, which are commonly used for stock solution preparation in biological assays.
The free amine group renders the compound basic, and it may form salts with common acids, potentially improving crystallinity or stability in certain formulations. Researchers are advised to verify solubility empirically for their specific application conditions. Exact solubility data should be confirmed with the certificate of analysis supplied with each lot.
Storage, Handling, and Safety
1-Ethyl-3-methyl-1H-pyrazol-5-amine should be stored in a tightly sealed container, away from heat, light, and moisture, at room temperature or as specified on the product label and certificate of analysis. Proper inert-atmosphere storage (e.g., under argon or nitrogen) is recommended if the compound shows sensitivity to air or moisture upon extended exposure.
Standard laboratory precautions apply: wear appropriate personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. Work in a well-ventilated area or fume hood when handling bulk quantities. Consult the Safety Data Sheet (SDS) for detailed hazard classification, first-aid measures, and disposal guidelines before use.
Research Applications
Aminopyrazoles such as 1-Ethyl-3-methyl-1H-pyrazol-5-amine serve as important building blocks in medicinal chemistry programs. The reactive primary amine at C-5 allows condensation with aldehydes, ketones, acid chlorides, isocyanates, and other electrophiles, enabling rapid assembly of diverse heterocyclic libraries.
Typical applications include the synthesis of pyrazolo-fused ring systems, urea and amide derivatives, Schiff base ligands for coordination chemistry, and pharmacophore exploration in drug discovery campaigns. The N-ethyl substitution at N-1 distinguishes this compound from N-methyl or N-unsubstituted analogues, offering different steric and electronic profiles for structure–activity relationship (SAR) studies.
Quality, Purity, and Ordering Information
Aladdin Scientific supplies 1-Ethyl-3-methyl-1H-pyrazol-5-amine under SKU E700645. Each lot is accompanied by a certificate of analysis (CoA) detailing purity, analytical data (such as NMR or HPLC), and batch-specific information. Researchers requiring high-purity material for sensitive assays should request the CoA prior to ordering to confirm suitability.
For bulk quantities, custom synthesis inquiries, or technical support regarding this compound, contact Aladdin Scientific's customer service team. Pricing, availability, and packaging options can be confirmed through the product page or procurement channels.
Frequently asked questions
What is the molecular formula and molecular weight of 1-Ethyl-3-methyl-1H-pyrazol-5-amine?
The molecular formula of 1-Ethyl-3-methyl-1H-pyrazol-5-amine is C6H11N3, and its molecular weight is approximately 125.17 g/mol. These values should be confirmed against the certificate of analysis supplied with each lot from Aladdin Scientific (SKU E700645).
What solvents are recommended for dissolving 1-Ethyl-3-methyl-1H-pyrazol-5-amine?
This aminopyrazole is expected to dissolve well in polar protic solvents such as water, methanol, and ethanol, as well as in polar aprotic solvents like DMSO and DMF. Researchers should verify solubility empirically under their specific experimental conditions and consult the CoA for any lot-specific solubility data.
What are the main applications of 1-Ethyl-3-methyl-1H-pyrazol-5-amine in research?
This compound is primarily used as a synthetic building block and intermediate in medicinal chemistry. Its C-5 primary amine reacts with aldehydes, acid chlorides, isocyanates, and other electrophiles to generate amides, ureas, Schiff bases, and fused heterocyclic scaffolds relevant to drug discovery and SAR studies.
How should 1-Ethyl-3-methyl-1H-pyrazol-5-amine be stored to maintain stability?
Store the compound in a tightly sealed container, away from heat, light, and moisture, following the conditions specified on the product label and certificate of analysis. If the material shows air or moisture sensitivity, storage under an inert atmosphere (argon or nitrogen) is advisable.
How do I obtain a Certificate of Analysis (CoA) or Safety Data Sheet (SDS) for SKU E700645?
The CoA and SDS for E700645 can be requested directly through Aladdin Scientific's product page or by contacting customer service with your lot number. The CoA provides purity, analytical data, and batch-specific details, while the SDS contains full hazard and handling information.
References
- Aladdin Scientific Product Listing: 1-Ethyl-3-methyl-1H-pyrazol-5-amine, SKU E700645.
- General reference: Elguero, J. Pyrazoles. In Comprehensive Heterocyclic Chemistry; Katritzky, A. R., Ed.; Pergamon: Oxford. (Textbook-level background on aminopyrazole chemistry.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
危险品化学品经营许可证（带存储）