What Is 1,2,3,4-Tetrachloronaphthalene?

1,2,3,4-Tetrachloronaphthalene (CAS 1825-31-6) is a member of the polychlorinated naphthalene (PCN) congener group, formed by substituting four chlorine atoms at the 1, 2, 3, and 4 positions of the naphthalene ring system. Its molecular formula is C₁₀H₄Cl₄ and its molecular weight is approximately 265.95 g/mol.

PCNs as a class are structurally analogous to polychlorinated biphenyls (PCBs) and dioxins, sharing similar planar aromatic architectures that contribute to their environmental persistence and biological activity. 1,2,3,4-Tetrachloronaphthalene is of particular interest in analytical and environmental chemistry as a reference congener for studying the distribution, fate, and toxicity of PCNs in environmental matrices.

Aladdin Scientific supplies this compound under SKU T1539463 for use as a research-grade reagent and analytical standard.

Key Physicochemical Properties

1,2,3,4-Tetrachloronaphthalene is typically a white to off-white crystalline solid at room temperature. Key physicochemical characteristics relevant to laboratory handling and environmental behavior include:

• Molecular Formula: C₁₀H₄Cl₄
• Molecular Weight: ~265.95 g/mol
• Log K_ow: High lipophilicity expected for a tetrachlorinated naphthalene congener, contributing to bioaccumulation potential (exact value should be confirmed against peer-reviewed literature).
• Solubility: Low water solubility; soluble in common organic solvents such as dichloromethane, hexane, acetone, and toluene.
• Stability: Chemically stable under ambient conditions; resistant to hydrolysis and photodegradation relative to many other organic compounds, consistent with PCN class behavior.

Note: Researchers should consult the product Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for lot-specific data including melting point, purity, and spectroscopic confirmation.

Research Applications

1,2,3,4-Tetrachloronaphthalene serves several important roles in scientific research:

1. Analytical Reference Standard: Used to calibrate and validate gas chromatography–mass spectrometry (GC-MS) and high-resolution mass spectrometry (HRMS) methods for quantifying PCN congeners in environmental samples such as soil, sediment, water, air, and biological tissues.
2. Environmental Monitoring: As a specific PCN congener, it is used to study the distribution and fate of polychlorinated naphthalenes released from industrial processes, including metal smelting and waste incineration.
3. Toxicological Research: PCNs including tetrachloronaphthalene congeners have been studied for Ah receptor (AhR) binding activity and potential to induce CYP1A enzymes, making this compound relevant to mechanistic toxicology studies.
4. Synthetic Chemistry: May be used as a starting material or intermediate in the synthesis of more complex halogenated aromatic structures.

Researchers in environmental chemistry, analytical chemistry, toxicology, and materials science will find this compound a useful addition to their reference standard libraries.

Safe Handling, Storage, and Disposal

As a chlorinated aromatic compound, 1,2,3,4-Tetrachloronaphthalene requires careful handling in a properly equipped laboratory environment. General precautionary guidance includes:

• Personal Protective Equipment (PPE): Wear appropriate chemical-resistant gloves, safety goggles, and a laboratory coat. Work in a fume hood to minimize inhalation exposure to dust or vapors.
• Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area, away from heat sources, open flames, and incompatible materials such as strong oxidizers. Follow lot-specific SDS instructions.
• Disposal: Dispose of as halogenated organic waste in accordance with all applicable local, regional, and national regulations. Do not pour down the drain or into the environment.
• Spill Response: Contain spills immediately using inert absorbent material. Avoid generating dust. Collect waste in appropriately labeled, sealable containers for compliant disposal.

Important: Always consult the current Safety Data Sheet (SDS) provided by Aladdin Scientific for lot-specific hazard information, GHS classification, first-aid measures, and regulatory data before use.

Ordering and Regulatory Considerations

1,2,3,4-Tetrachloronaphthalene (SKU: T1539463) is available from Aladdin Scientific for research and analytical purposes. When ordering, please note the following:

• Intended Use: This product is intended for laboratory research use only. It is not approved for use in food, drug, or cosmetic applications.
• Regulatory Status: Polychlorinated naphthalenes as a class may be subject to import, export, or use restrictions under environmental regulations in various jurisdictions. Buyers are responsible for verifying applicable regulatory requirements in their region prior to purchase and use.
• Documentation: A Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are available upon request. Contact Aladdin Scientific customer service for lot-specific documentation.
• Quantity and Packaging: Please refer to the current product listing on the Aladdin Scientific website for available pack sizes, pricing, and lead times.

For technical inquiries regarding purity specifications, analytical methods, or custom requirements, please contact Aladdin Scientific technical support.