What Is 2,3,5,6-Tetrabromo-1,4-dichlorobenzene?

2,3,5,6-Tetrabromo-1,4-dichlorobenzene (SKU: T708652) is a symmetrically substituted polyhalogenated benzene in which all six ring positions are occupied by halogen atoms — four bromine substituents at the 2, 3, 5, and 6 positions and two chlorine substituents at the 1 and 4 positions. Its molecular formula is C₆Br₄Cl₂.

The compound belongs to the broader class of polyhalogenated aromatic hydrocarbons (PHAHs). The high degree of halogenation renders the aromatic ring highly electron-deficient, which governs its reactivity profile and physical properties such as elevated melting point and low volatility relative to less-substituted benzene derivatives.

Researchers use this compound as a synthetic intermediate, a model substrate for studying halogen-exchange (Finkelstein-type) reactions on aromatic systems, and as an analytical reference standard for environmental and toxicological studies of halogenated aromatics.

Physical and Chemical Properties

As a perhalogenated benzene derivative, 2,3,5,6-tetrabromo-1,4-dichlorobenzene exhibits several characteristic properties common to this compound class:

• Appearance: Typically a white to off-white crystalline solid at room temperature.
• Solubility: Sparingly soluble in water; more soluble in common organic solvents such as chloroform, dichloromethane, and tetrahydrofuran, consistent with its highly nonpolar, halogen-rich structure.
• Thermal stability: The fully halogenated ring confers good thermal stability; the compound is expected to have a relatively high melting point compared to partially halogenated analogues.
• Electron deficiency: The combined inductive withdrawal of four Br and two Cl atoms makes the ring highly electron-poor, favouring nucleophilic aromatic substitution (SNAr) reactions rather than electrophilic substitution.

Note: Specific numerical values for melting point, boiling point, and density are not confirmed in the source material and should be verified against the product specification sheet (SDS/TDS) available on the Aladdin Scientific website.

Applications in Research

2,3,5,6-Tetrabromo-1,4-dichlorobenzene finds use across several research domains:

1. Synthetic chemistry: The compound serves as a precursor or intermediate in the synthesis of more complex polyhalogenated aromatics, including potential pharmaceutical and agrochemical building blocks. Selective halogen–metal exchange at bromine positions (e.g., lithiation) can introduce diverse functional groups.
2. Materials science: Fully halogenated benzenes are studied as components in organic semiconductors and as precursors to halogen-bonded co-crystals and supramolecular assemblies, where the bromine atoms act as halogen-bond donors.
3. Analytical reference standards: Polyhalogenated benzenes are used as internal standards or calibrants in gas chromatography–mass spectrometry (GC-MS) methods for environmental monitoring of halogenated pollutants.
4. Mechanistic studies: This compound is a model substrate for investigating nucleophilic aromatic substitution kinetics and selectivity on electron-deficient rings.

Handling, Safety and Storage

As with all halogenated aromatic compounds, appropriate laboratory safety precautions must be observed when handling 2,3,5,6-tetrabromo-1,4-dichlorobenzene:

• Personal protective equipment (PPE): Wear chemically resistant gloves, a laboratory coat, and safety glasses. Work in a well-ventilated fume hood to minimise inhalation of dust or vapours.
• Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area, away from incompatible materials such as strong oxidisers and bases. Keep away from heat and ignition sources.
• Waste disposal: Dispose of in accordance with local, regional, and national regulations governing halogenated organic waste.
• SDS: Always consult the current Safety Data Sheet (SDS) supplied by Aladdin Scientific before use. Specific hazard classifications (GHS pictograms, H- and P-statements) should be confirmed from the official SDS for SKU T708652.

Note: Specific GHS hazard category assignments and R/S or H/P statement numbers are not confirmed in the source material; review the official SDS before use.

Ordering and Availability

2,3,5,6-Tetrabromo-1,4-dichlorobenzene is available from Aladdin Scientific under SKU T708652. To place an order or request additional information:

• Visit the Aladdin Scientific website and search for SKU T708652 or the full IUPAC name.
• Contact our customer service team for bulk quantities, custom packaging, or certificate-of-analysis requests.
• Registered account holders can track orders, access invoices, and manage reward points through the online portal.
• For institutional or procurement enquiries, our sales team can provide formal quotations and assist with purchase order processes.

Purity grade, pack sizes, and pricing are listed on the product detail page and are subject to change; please confirm current specifications at the time of ordering.