What Is 2,4,6-Trimethyl-1,3,5-Triazine?

2,4,6-Trimethyl-1,3,5-triazine (CAS 1004-36-0, SKU T1529555) is a fully symmetric triazine derivative in which all three reactive positions of the 1,3,5-triazine ring are occupied by methyl groups. The compound belongs to the s-triazine family of electron-deficient aromatic heterocycles. Its high degree of molecular symmetry, combined with the electron-withdrawing nature of the triazine ring, makes it a versatile platform for further chemical elaboration.

The molecular formula is C₆H₉N₃ with a molecular weight of 123.16 g/mol. The three ring nitrogen atoms confer Lewis-basic character, enabling coordination to metal centers, while the methyl groups provide handles for functionalization via radical, oxidative, or deprotonation pathways.

Physical and Chemical Properties

2,4,6-Trimethyl-1,3,5-triazine is typically encountered as a colorless to pale yellow liquid or low-melting crystalline solid at ambient temperature. Key physical properties include its relatively low molecular weight (123.16 g/mol) and the aromatic stabilization provided by the triazine ring system, which contributes to its thermal stability compared with non-aromatic analogues.

The compound is soluble in common organic solvents such as dichloromethane, acetonitrile, ethyl acetate, tetrahydrofuran, and dimethylformamide. Its electron-deficient ring makes it susceptible to nucleophilic attack at the ring carbons under forcing conditions, a property exploited in ring-opening and cyclocondensation reactions. The methyl groups can be selectively oxidized or halogenated, providing pathways to hydroxymethyl, carboxaldehyde, or halomethyl triazine derivatives.

Research Applications

The compound serves multiple roles in research and applied chemistry:

• Organic synthesis building block: The symmetric triazine scaffold is a starting material for the preparation of unsymmetric 1,3,5-triazines, which are important in agrochemicals, pharmaceuticals, and functional materials.
• Coordination chemistry: The three nitrogen atoms of the triazine ring can act as ligands for transition metals, and 2,4,6-trimethyl-1,3,5-triazine has been studied as a ligand precursor in metal-organic frameworks and supramolecular assemblies.
• Materials science: Triazine-based polymers and covalent triazine frameworks (CTFs) are of interest for gas adsorption, catalysis, and energy storage; methyltriazines serve as model compounds and monomers in such studies.
• Analytical reference standard: The compound's well-defined structure and commercial availability make it useful as an internal standard or reference in spectroscopic and chromatographic method development.

Safe Handling, Storage, and Regulatory Considerations

As with all chemical reagents, appropriate safety precautions should be observed when working with 2,4,6-trimethyl-1,3,5-triazine. Users should consult the current Safety Data Sheet (SDS) provided by Aladdin Scientific before use. General precautions for this class of compound include:

• Handle in a well-ventilated fume hood to avoid inhalation of vapors.
• Use appropriate personal protective equipment (PPE): lab coat, chemical-resistant gloves, and safety goggles.
• Store in a tightly sealed container, away from heat sources, oxidizers, and strong acids or bases, in a cool, dry location consistent with supplier recommendations.
• Dispose of waste in accordance with local institutional and governmental regulations for organic solvent and nitrogen-heterocycle waste streams.

Note: Always refer to the current product SDS for authoritative hazard, handling, and disposal information specific to this lot and grade.

Ordering and Availability

2,4,6-Trimethyl-1,3,5-triazine is available from Aladdin Scientific under SKU T1529555. Researchers and procurement teams can request pricing, quantity options, and current stock availability through the Aladdin Scientific website or by contacting customer service directly. Custom pack sizes or bulk quantities may be available upon request; please inquire with the sales team for details.

For questions regarding purity specifications, certificate of analysis (CoA), or technical data, contact Aladdin Scientific technical support. All products are subject to Aladdin's standard terms regarding payment, shipping, and returns as described in the relevant policy sections of the website.