What Is 2-Amino-5-fluoro-4-methylbenzoic Acid?

2-Amino-5-fluoro-4-methylbenzoic acid (CAS catalog SKU A727622) is a substituted benzoic acid derivative in which the benzene ring carries an amino group at the 2-position, a fluorine atom at the 5-position, and a methyl group at the 4-position. The simultaneous presence of an electron-donating amino group, an electron-withdrawing carboxylic acid, and an aryl fluoride makes this compound a versatile bifunctional intermediate for organic synthesis.

The compound belongs to the broader class of fluorinated aromatic building blocks that are valued in drug discovery for their ability to modulate lipophilicity, metabolic stability, and binding affinity of candidate molecules. The free amino and carboxyl groups each offer independent handles for further derivatization via amide coupling, esterification, diazotization, or heterocycle formation.

Typical Research and Synthetic Applications

As a bifunctional aromatic intermediate, 2-Amino-5-fluoro-4-methylbenzoic acid is commonly employed in the following contexts:

• Pharmaceutical intermediate synthesis: The compound serves as a starting material or key intermediate for the preparation of benzoxazinone, quinazoline, quinolone, and related nitrogen-containing heterocyclic scaffolds encountered in drug candidates.
• Amide and peptide coupling: The carboxylic acid can be activated and coupled with amines to form amide bonds using standard reagents such as EDC/HOBt or HATU.
• Diazotization chemistry: The aromatic amine can be converted to a diazonium salt and subsequently used in Sandmeyer reactions or azo dye synthesis.
• Fluorine-directed C–H functionalization: The aryl fluoride is amenable to nucleophilic aromatic substitution (SNAr) under appropriate conditions, enabling introduction of diverse nucleophiles.

These applications make the compound relevant to medicinal chemistry, agrochemical research, and materials science programs requiring fluorinated aromatic scaffolds.

Handling, Storage, and Safety Considerations

Although specific GHS hazard data for 2-Amino-5-fluoro-4-methylbenzoic acid should be confirmed in the product Safety Data Sheet (SDS) provided by Aladdin Scientific, the following general guidance applies to compounds of this class:

• Personal protective equipment: Wear nitrile gloves, laboratory coat, and safety goggles when handling the solid or its solutions. Work in a well-ventilated area or fume hood.
• Storage: Store in a tightly sealed container in a cool, dry location away from strong oxidizers and strong bases. Refrigerated storage (2–8 °C) is recommended to maintain long-term stability.
• Disposal: Dispose of waste in accordance with local regulations for fluorinated aromatic compounds.

Always consult the current SDS before use. Specific hazard classifications, first-aid measures, and transport requirements are detailed therein.

Ordering and Product Specifications

2-Amino-5-fluoro-4-methylbenzoic acid is available from Aladdin Scientific under catalog number A727622. When placing an order, researchers and procurement teams should confirm the following with Aladdin customer service or the product detail page:

• Available pack sizes and pricing
• Purity specification and analytical certificate (CoA) availability
• Current stock status and lead time for out-of-stock quantities
• Bulk or custom synthesis quotation if standard pack sizes are insufficient

For questions about specifications, grades, or purity standards, please contact Aladdin Scientific technical support or refer to the published CoA accompanying each lot.