Chemical Structure and Key Properties

2-Amino-5-fluoro-4-methylbenzoic acid is a substituted benzoic acid derivative with the following substituents on the benzene ring: an amino group (–NH2) at the 2-position (ortho to the carboxylic acid), a fluorine atom at the 5-position, and a methyl group at the 4-position. Its molecular formula is C₈H₈FNO₂ with a molecular weight of approximately 169.15 g/mol.

The combination of electron-donating (–NH2, –CH3) and electron-withdrawing (–F, –COOH) substituents creates a compound with a well-defined electronic profile suited for directed synthetic transformations. The fluorine atom, owing to its strong electronegativity and small steric size, modulates the reactivity and lipophilicity of the molecule—properties that are highly valued in medicinal chemistry programs.

Note: The exact melting point, purity specification, and CAS number should be confirmed against the current Aladdin Scientific certificate of analysis for SKU A727622.

Applications in Pharmaceutical and Fine-Chemical Synthesis

Fluorinated aminobenzoic acid derivatives are widely employed as building blocks in drug discovery and development. The free amino and carboxylic acid groups in 2-Amino-5-fluoro-4-methylbenzoic acid enable straightforward coupling reactions, cyclizations, and functional-group interconversions:

• Amide bond formation: The carboxylic acid can be activated (e.g., via acyl chloride, mixed anhydride, or coupling reagents such as HATU/EDC) to form amides with amines, yielding peptidomimetic or heterocyclic scaffolds.
• Heterocycle synthesis: The ortho-amino/carboxylic acid arrangement is a classic precursor for benzoxazole, benzimidazole, and quinazoline ring systems, which appear frequently in bioactive molecules.
• Fluorine as a metabolic blocker: The C–F bond introduced into drug candidates can block cytochrome P450-mediated oxidation at that position, improving metabolic stability.
• SNAr reactions: Activated aryl fluorides participate in nucleophilic aromatic substitution, although the fluorine in this compound is not at a highly activated position; reactivity should be assessed experimentally.

These attributes make SKU A727622 a useful reagent for medicinal chemists designing kinase inhibitors, antibiotics, or other small-molecule therapeutics.

Handling, Storage, and Safety Considerations

As with most aromatic amines and fluorinated organic compounds, appropriate laboratory safety precautions should be observed when handling 2-Amino-5-fluoro-4-methylbenzoic acid:

• Personal Protective Equipment (PPE): Wear nitrile gloves, a laboratory coat, and safety glasses. Use a fume hood when weighing or dissolving the compound.
• Storage: Store in a tightly sealed container in a cool, dry place, away from light and incompatible materials (strong oxidizers, strong bases). Typical storage temperature is room temperature unless otherwise specified on the product label.
• Solubility: The compound is expected to show solubility in polar organic solvents such as DMSO, DMF, methanol, and ethanol. Aqueous solubility may be limited at neutral pH but can improve under basic conditions due to deprotonation of the carboxylic acid.
• Disposal: Dispose of waste in accordance with local regulations for organic chemical waste.

Always consult the Safety Data Sheet (SDS) for SKU A727622 on the Aladdin Scientific website before use. Specific hazard classifications, GHS pictograms, and first-aid measures are detailed therein.

Ordering and Specifications

2-Amino-5-fluoro-4-methylbenzoic acid is available from Aladdin Scientific under SKU A727622. To place an order or request a quotation:

• Visit the Aladdin Scientific website and search for SKU A727622.
• Select the required pack size and purity grade from the available options.
• For bulk quantities or custom purity requirements, contact the Aladdin Scientific sales team directly.

A certificate of analysis (CoA) confirming purity, appearance, and analytical data (e.g., NMR, HPLC) is available upon request or can be downloaded from the product page. Shipping conditions comply with applicable regulations for research-grade organic chemicals.

Note: Specific pack sizes, pricing, and current stock availability are subject to change; please check the product listing for up-to-date information.