2-Chloro-3-methoxyphenol: Properties, Uses & Handling FAQ
2-Chloro-3-methoxyphenol: Properties, Uses & Handling FAQ
2-Chloro-3-methoxyphenol is a halogenated phenolic compound used as a versatile building block in organic synthesis and pharmaceutical research.
- Chemical Name
- 2-Chloro-3-methoxyphenol
- CAS Number
- 7368-77-6
- Molecular Formula
- C₇H₇ClO₂
- Molecular Weight
- 158.58 g/mol
- SKU
- C194760
- Functional Groups
- Phenol (–OH), Methoxy (–OCH₃), Chloro (–Cl)
What Is 2-Chloro-3-methoxyphenol?
2-Chloro-3-methoxyphenol (CAS 7368-77-6, SKU C194760) is an aromatic organic compound featuring a phenol ring substituted with a chlorine atom at the 2-position and a methoxy group at the 3-position. Its molecular formula is C₇H₇ClO₂ with a molecular weight of approximately 158.58 g/mol. The compound belongs to the class of halogenated guaiacol-related phenolics and is of interest as a synthetic intermediate in organic and medicinal chemistry. The presence of three distinct functional groups—hydroxyl, methoxy, and chloro—on the aromatic ring imparts reactivity suitable for cross-coupling reactions, etherification, and further functionalization.
Purity, Grade, and Analytical Specifications
Aladdin Scientific supplies 2-Chloro-3-methoxyphenol (C194760) as a research-grade reagent. Researchers should consult the certificate of analysis (CoA) provided with each lot for confirmed purity, appearance, and analytical data including NMR and/or GC purity. If specific purity grades or custom specifications are required for your application, please contact Aladdin's technical support team to discuss available options. Always verify the CoA data against your experimental requirements before use.
Storage, Stability, and Handling
As a phenolic compound containing a reactive hydroxyl group and an aryl chloride moiety, 2-Chloro-3-methoxyphenol should be stored in a cool, dry, well-ventilated location away from direct light, heat sources, and incompatible materials such as strong oxidizers and strong bases. The container should be kept tightly sealed to prevent moisture absorption and oxidation. Researchers are advised to wear appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and a lab coat when handling this compound. Consult the Safety Data Sheet (SDS) for full hazard information, first-aid measures, and disposal guidance before use.
Research and Synthetic Applications
2-Chloro-3-methoxyphenol serves primarily as a synthetic building block in pharmaceutical and fine-chemical research. Its aryl chloride functionality makes it amenable to transition-metal-catalyzed cross-coupling reactions such as Suzuki, Buchwald-Hartwig, and Ullmann-type couplings, enabling the construction of more complex biaryl or heteroaryl architectures. The free phenolic hydroxyl group can be selectively alkylated or acylated, while the methoxy group can serve as a directing group in electrophilic aromatic substitution. These combined features make it a valuable intermediate in the preparation of biologically active molecules, agrochemicals, and advanced material precursors.
Ordering, Packaging, and Technical Support
2-Chloro-3-methoxyphenol is available from Aladdin Scientific under SKU C194760. To place an order, visit the Aladdin Scientific website, search by product name or SKU, and select the desired pack size and quantity. For bulk or custom quantity inquiries, custom synthesis requests, or technical questions regarding suitability for a specific application, please reach out to Aladdin's customer service or technical support teams directly. Lot-specific CoA and SDS documents are available on the product page or upon request.
Frequently asked questions
What is the CAS number for 2-Chloro-3-methoxyphenol?
The CAS registry number for 2-Chloro-3-methoxyphenol is 7368-77-6. Aladdin Scientific lists this compound under SKU C194760. Always cross-reference the CAS number with the product CoA to confirm identity before use.
What solvents are suitable for dissolving 2-Chloro-3-methoxyphenol?
As a moderately polar phenolic compound, 2-Chloro-3-methoxyphenol is generally soluble in common organic solvents such as ethanol, methanol, acetone, dichloromethane, and ethyl acetate. Its solubility in water is expected to be limited due to the hydrophobic chloro and methoxy substituents. Researchers should perform solubility tests at the working concentration required for their specific application.
How should 2-Chloro-3-methoxyphenol be stored to maintain stability?
Store 2-Chloro-3-methoxyphenol in a tightly sealed container in a cool, dry, and well-ventilated area, away from light, heat, and incompatible reagents such as strong oxidizing agents and strong bases. Under these recommended conditions, the compound is expected to remain stable for an extended period. Refer to the product SDS and CoA for lot-specific storage recommendations.
Is 2-Chloro-3-methoxyphenol suitable for use in cross-coupling reactions?
Yes, the aryl chloride moiety in 2-Chloro-3-methoxyphenol makes it a viable electrophilic partner in transition-metal-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Ullmann-type couplings, though aryl chlorides may require more active catalyst systems compared to aryl bromides or iodides. The phenolic hydroxyl group must be protected or selectively managed depending on the reaction conditions employed.
How can I obtain the Safety Data Sheet (SDS) for 2-Chloro-3-methoxyphenol?
The Safety Data Sheet for 2-Chloro-3-methoxyphenol (SKU C194760) is available on the Aladdin Scientific product page. You may also request the SDS directly from Aladdin's customer service team. Always review the SDS prior to handling any chemical reagent to ensure appropriate safety precautions are in place.
References
- CAS Registry: 2-Chloro-3-methoxyphenol, CAS No. 7368-77-6. SciFinder / CAS Common Chemistry.
- Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry, 2nd ed.; Oxford University Press: Oxford, 2012. (General reference for phenol chemistry and cross-coupling reactions.)
- Aladdin Scientific Product Page: 2-Chloro-3-methoxyphenol, SKU C194760.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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