2-Chloro-N-(cyclohexylcarbamoyl)acetamide: Properties & FAQs
2-Chloro-N-(cyclohexylcarbamoyl)acetamide: Properties & FAQs
2-Chloro-N-(cyclohexylcarbamoyl)acetamide is a bifunctional organic compound featuring both a reactive chloroacetamide moiety and a cyclohexyl urea segment, making it a versatile intermediate for synthetic chemistry research.
- Product Name
- 2-Chloro-N-(cyclohexylcarbamoyl)acetamide
- SKU
- C191376
- Functional Groups
- Chloroacetamide and cyclohexylurea
- Primary Application
- Synthetic intermediate in organic and medicinal chemistry research
- Supplier
- Aladdin Scientific
- Handling Precaution
- Handle with care; chloroacetamide derivatives are reactive alkylating agents — use appropriate PPE
What Is 2-Chloro-N-(cyclohexylcarbamoyl)acetamide?
2-Chloro-N-(cyclohexylcarbamoyl)acetamide (SKU: C191376) is an organic compound that combines two pharmacophoric elements: a chloroacetamide group, which serves as an electrophilic warhead capable of alkylating nucleophilic residues, and a cyclohexyl urea moiety, which contributes to hydrogen-bonding capacity and lipophilicity. This structural combination makes the compound a useful building block in the synthesis of more complex molecules for biological or materials research.
The compound belongs to the broader class of chloroacetamide derivatives, which are well-established in synthetic organic chemistry as versatile intermediates. The urea linkage in the molecule provides additional conformational rigidity and opportunities for further functionalization.
Safe Handling, Storage, and Stability
As with all chloroacetamide-class compounds, 2-Chloro-N-(cyclohexylcarbamoyl)acetamide should be handled with appropriate personal protective equipment (PPE), including nitrile gloves, safety glasses, and a lab coat. Work should be performed in a well-ventilated area or fume hood, as chloroacetamide derivatives are reactive alkylating agents that may be irritating to skin, eyes, and the respiratory tract.
For storage, the compound should be kept in a tightly sealed container, away from moisture, heat, and incompatible materials such as strong bases and nucleophiles, which can react with the electrophilic chloroacetamide group. Storage at cool, dry conditions (typically 2–8 °C or room temperature as specified on the product Certificate of Analysis) is recommended to preserve stability. Always consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use.
Typical Research Applications
2-Chloro-N-(cyclohexylcarbamoyl)acetamide is primarily used as a synthetic intermediate in organic and medicinal chemistry. The reactive chloroacetamide moiety allows coupling reactions with thiol-containing compounds, amines, and other nucleophiles, enabling the construction of diverse molecular scaffolds.
Researchers may employ this compound in the preparation of covalent inhibitors or as a fragment for structure-activity relationship (SAR) studies. The cyclohexyl urea segment can serve as a bioisostere or a hydrogen-bond donor/acceptor unit in drug discovery programs. It may also find utility as a building block in the synthesis of heterocyclic compounds through intramolecular cyclization reactions.
Ordering, Purity, and Quality Specifications
2-Chloro-N-(cyclohexylcarbamoyl)acetamide is available from Aladdin Scientific under SKU C191376. Researchers and procurement teams can place orders through the Aladdin Scientific website or by contacting the sales team directly. Bulk quantities and custom packaging may be available upon request.
Each lot of C191376 is accompanied by a Certificate of Analysis (CoA) documenting purity, appearance, and analytical data. For specific purity grades, lot-specific data, or regulatory documentation such as SDS, please contact Aladdin Scientific customer support or visit the product page on the Aladdin website. If you require additional characterization data (e.g., NMR, HPLC traces), please inquire at the time of ordering.
Troubleshooting Common Issues
If you observe unexpected reactivity or decomposition of 2-Chloro-N-(cyclohexylcarbamoyl)acetamide during use, the most common causes are exposure to moisture, elevated temperature, or the presence of nucleophilic solvents or reagents that react with the chloroacetamide group. Ensure the compound is stored and handled under anhydrous conditions where possible.
If the product does not meet the specifications stated in the CoA upon receipt, contact Aladdin Scientific's customer service team promptly with your lot number and a description of the issue. Aladdin Scientific's returns and refunds policy covers products that do not conform to stated specifications — please refer to the returns and refunds section of the website for further details.
Frequently asked questions
What is the CAS number or molecular formula of 2-Chloro-N-(cyclohexylcarbamoyl)acetamide?
The CAS number and full molecular formula for 2-Chloro-N-(cyclohexylcarbamoyl)acetamide (C191376) are not listed in our current source material. Please visit the product page on the Aladdin Scientific website or contact our technical support team for the confirmed CAS number, molecular formula, and molecular weight.
How should I store 2-Chloro-N-(cyclohexylcarbamoyl)acetamide to ensure stability?
Store 2-Chloro-N-(cyclohexylcarbamoyl)acetamide in a tightly sealed container under cool, dry conditions, away from moisture, strong nucleophiles, and strong bases. Refer to the Certificate of Analysis and Safety Data Sheet provided with your lot for lot-specific storage temperature recommendations.
Can I use 2-Chloro-N-(cyclohexylcarbamoyl)acetamide as a covalent warhead in drug discovery?
The chloroacetamide group in this compound is a well-recognized electrophilic warhead that can react with nucleophilic residues such as cysteine thiols, making it a candidate building block for covalent inhibitor design. However, specific biological activity data for this compound is not available in our current source material; researchers should conduct their own in vitro assays to evaluate suitability for their target.
What analytical data is available for lot-specific quality verification of C191376?
Each lot of C191376 from Aladdin Scientific is supplied with a Certificate of Analysis (CoA) that includes purity and appearance data. For additional analytical data such as NMR spectra or HPLC traces, please contact Aladdin Scientific customer support at the time of ordering or upon receipt of your shipment.
What safety precautions should be taken when working with this compound?
Always wear appropriate PPE including nitrile gloves, safety glasses, and a lab coat. Handle the compound in a fume hood, as chloroacetamide derivatives can be irritating to skin, eyes, and the respiratory tract. Consult the SDS before use and dispose of waste in accordance with local regulations.
References
- Aladdin Scientific product page for 2-Chloro-N-(cyclohexylcarbamoyl)acetamide, SKU C191376.
- General reference: March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley. (Standard textbook-level source for chloroacetamide reactivity.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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