What Is 2-(Isopropylamino)-1,3-thiazole-4-carboxylic Acid?

2-(Isopropylamino)-1,3-thiazole-4-carboxylic acid (Aladdin SKU: T726373) is a substituted aminothiazole derivative bearing an isopropylamino group at the 2-position and a carboxylic acid at the 4-position of the thiazole ring. The 1,3-thiazole scaffold is a five-membered aromatic heterocycle containing both sulfur and nitrogen atoms, widely employed as a privileged structure in medicinal chemistry due to its metabolic stability and favorable pharmacokinetic profile. The free carboxylic acid group enables straightforward amide coupling, esterification, and other condensation reactions, while the secondary amine at the 2-position provides an additional site for further functionalization or hydrogen-bond interactions.

Handling, Storage and Safety Considerations

As with most heterocyclic carboxylic acid reagents, standard laboratory precautions should be observed when handling 2-(Isopropylamino)-1,3-thiazole-4-carboxylic acid. Personal protective equipment including gloves, a laboratory coat, and eye protection is recommended. The compound should be stored in a tightly sealed container under cool, dry conditions, away from direct light and moisture to prevent degradation of the free carboxylic acid and the aminothiazole moiety. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for compound-specific hazard classifications, first-aid measures, and disposal guidance before use.

If working with milligram-scale quantities for synthesis, weigh the solid in a well-ventilated area or fume hood. Avoid prolonged skin contact or inhalation of dust.

Typical Applications in Research and Synthesis

Aminothiazole carboxylic acids serve as valuable scaffolds and linkers in drug discovery programs. The carboxylic acid group of 2-(Isopropylamino)-1,3-thiazole-4-carboxylic acid can be activated for amide bond formation with amines using standard coupling reagents (e.g., HATU, EDC/HOBt), making it suitable for the construction of amide libraries or peptidomimetic structures. The isopropylamino substituent at the 2-position modulates the electron density of the thiazole ring and contributes lipophilicity, which may influence membrane permeability in biological assays.

This compound is also applicable as a fragment or building block in fragment-based drug discovery (FBDD), as a key intermediate in the synthesis of kinase inhibitors or antimicrobial agents featuring an aminothiazole pharmacophore, and in the preparation of fluorescent probes or dye intermediates where heteroaromatic cores are required.

Ordering and Availability from Aladdin Scientific

2-(Isopropylamino)-1,3-thiazole-4-carboxylic acid is listed in the Aladdin Scientific catalog under SKU T726373. To place an order, visit the Aladdin Scientific website, search for T726373, and add the desired quantity to your cart. Institutional purchase orders, online credit card payments, and other payment options may be available depending on your region. For bulk quotations, custom pack sizes, or questions about lead time and availability, contact Aladdin Scientific customer service directly.

Reward points, promotional coupons, and volume pricing may apply — please refer to the current promotions page or contact your regional sales representative for details.

Purity, Specifications and Quality Assurance

Aladdin Scientific supplies research-grade reagents with documented purity specifications. For 2-(Isopropylamino)-1,3-thiazole-4-carboxylic acid (T726373), purity and analytical data such as HPLC, NMR, or mass spectrometry confirmation are typically provided with each lot. Customers are encouraged to review the Certificate of Analysis (CoA) available on the product page or upon request to verify that the compound meets the requirements of their specific application.

If your research requires material of a defined minimum purity or a specific grade (e.g., for biological assays versus synthetic use), please confirm specifications with Aladdin Scientific prior to ordering to ensure suitability.