Chemical Identity and Structure

3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid (SKU P709791) is a member of the fluorinated cinnamic acid family. Its structure consists of a trans-acrylic acid side chain conjugated to a phenyl ring bearing an ortho-fluoro substituent and a para-trifluoromethyl group. This combination of electron-withdrawing fluorine atoms profoundly influences the compound's electronic character, lipophilicity (logP), and metabolic stability compared to non-fluorinated analogues. The molecular formula is C₁₀H₆F₄O₂, and the compound possesses a carboxylic acid functional group amenable to a wide range of synthetic transformations including esterification, amide coupling, and decarboxylation.

Applications in Research and Synthesis

This compound serves as a key building block in several research domains:

• Medicinal Chemistry: Fluorinated arylacrylic acids are established pharmacophoric fragments used to modulate receptor binding affinity, improve membrane permeability, and enhance metabolic resistance in drug candidates. The ortho-fluoro and para-trifluoromethyl substitution pattern is frequently encountered in CNS-active compounds and enzyme inhibitors.
• Agrochemical Synthesis: Fluorine-containing aromatic acids serve as intermediates in the preparation of modern herbicides, fungicides, and insecticides with improved bioavailability and environmental profiles.
• Materials Science: The acrylic acid moiety allows incorporation into polymer backbones via free-radical or controlled polymerization, imparting fluorine-derived surface properties such as low surface energy and chemical resistance.
• Suzuki and Cross-Coupling Precursors: The carboxylic acid can be converted to the corresponding acyl halide or boronate ester for use in palladium-catalyzed cross-coupling reactions.

Researchers should verify specific reaction conditions and yields in primary literature before scaling up.

Handling, Storage, and Safety Guidelines

Personal Protective Equipment (PPE): Always wear chemical-resistant gloves, safety glasses or goggles, and a laboratory coat when handling this compound. A dust/mist respirator may be required if powder aerosols are generated.

Engineering Controls: Conduct all weighing and transfers in a chemical fume hood to minimize inhalation exposure to fine particles or vapors. Fluorinated organic acids can be irritating to the respiratory tract, skin, and eyes.

Storage: Store the sealed container in a cool (2–25 °C recommended), dry location, protected from light and moisture. Keep away from strong bases, oxidizers, and reactive metals. Confirm exact storage requirements on the product-specific Certificate of Analysis (CoA).

Disposal: Dispose of waste material in accordance with local, regional, and national regulations for fluorinated organic compounds. Do not pour into drains or waterways.

First Aid: In case of skin or eye contact, flush immediately with copious water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air; consult a physician if symptoms persist.

Quality, Purity, and Ordering Information

Aladdin Scientific supplies 3-(2-Fluoro-4-(trifluoromethyl)phenyl)acrylic acid under SKU P709791. Each lot is accompanied by a Certificate of Analysis (CoA) confirming identity (typically by NMR and/or HPLC) and purity. Researchers are advised to:

• Request the CoA for the specific lot number received and verify purity meets the requirements of their application before use.
• Check the product page on the Aladdin Scientific website for current purity grade, pack sizes, and pricing.
• Contact Aladdin Scientific technical support for bulk quantities, custom grades, or application-specific questions.

For procurement teams, standard lead times and shipping conditions (ambient or cold-chain) should be confirmed at the time of order placement. Fluorinated compounds are typically stable under ambient shipping conditions when properly sealed, but cold-chain shipping may be recommended for extended transit times.