What Is 3-Amino-N-isopropylbenzamide?

3-Amino-N-isopropylbenzamide (CAS registry; molecular formula C₁₀H₁₄N₂O; MW 178.23 g/mol) is a meta-substituted benzamide bearing a free primary amino group at the 3-position of the benzene ring and an isopropyl substituent on the amide nitrogen. The coexistence of a nucleophilic aromatic amine and a hydrogen-bond-donating/accepting amide makes this compound a versatile bifunctional scaffold in synthetic chemistry. It is commercially available from Aladdin Scientific under catalog number A186750.

Research Applications and Use Cases

In medicinal chemistry, 3-Amino-N-isopropylbenzamide serves primarily as a building block for the synthesis of more complex drug-like molecules. The free amine can be elaborated via acylation, sulfonylation, reductive amination, or condensation reactions to introduce pharmacophoric elements. The amide moiety contributes rigidity and hydrogen-bonding capacity, properties often exploited when designing enzyme inhibitors or receptor modulators.

In materials and polymer chemistry, aminobenzamide derivatives are occasionally employed as chain extenders or crosslinkers in polyamide and polyurea systems. Researchers also use such bifunctional intermediates as linkers in bioconjugation and as precursors to heterocyclic ring formation (e.g., benzimidazolone or quinazolinone ring closures).

Handling, Storage, and Safety Guidelines

As with most primary aromatic amines, 3-Amino-N-isopropylbenzamide should be handled with appropriate personal protective equipment including nitrile gloves, safety glasses, and a laboratory coat. Operations generating dust or aerosol should be conducted in a well-ventilated fume hood. Aromatic amines as a class may present sensitization or health hazards; consult the product-specific Safety Data Sheet (SDS) provided by Aladdin Scientific before use.

For storage, keep the compound in a tightly sealed container, protected from light and moisture, at room temperature or as specified on the product label. Properly stored solid material is generally stable for an extended period; however, exact shelf-life data should be referenced from the product certificate of analysis (CoA).

Purity, Specifications, and Quality Assurance

Aladdin Scientific supplies 3-Amino-N-isopropylbenzamide (A186750) with a purity specification that is confirmed by analytical techniques such as HPLC or GC, as stated on the accompanying Certificate of Analysis. Lot-specific purity data, NMR confirmation, and moisture content (where relevant) are documented on each CoA, which is available upon request or through the Aladdin Scientific website.

For synthetic or biological assay work requiring higher purity, researchers may wish to recrystallize the material from a suitable solvent system (e.g., ethanol/water or ethyl acetate/hexane) prior to use. Verification of identity by ¹H NMR and mass spectrometry is recommended for critical applications.

Ordering and Customer Support

3-Amino-N-isopropylbenzamide is available directly from Aladdin Scientific under SKU A186750. Orders may be placed online through the Aladdin Scientific catalog or by contacting a regional sales representative. Bulk quantities, custom packaging, or additional analytical data may be requested by reaching out to the technical support or sales team. For questions regarding availability, lead times, or pricing, please contact Aladdin Scientific customer service directly.