3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine: FAQs & Key Facts
3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine: FAQs & Key Facts
3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine is a bifunctional heterocyclic building block featuring a reactive chloropyridazine core and a 4-methylimidazolyl substituent, making it a versatile intermediate for medicinal chemistry and drug discovery research.
- Product Name
- 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine
- SKU
- C188454
- Molecular Formula
- C8H7ClN4
- Molecular Weight
- 194.62 g/mol
- Core Scaffold
- Chloropyridazine fused with 4-methylimidazolyl group
- Primary Application
- Medicinal chemistry intermediate and heterocyclic building block
What Is 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine?
3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine (SKU: C188454) is a nitrogen-rich heterocyclic compound that combines a pyridazine ring bearing a chloro substituent at the 3-position with a 4-methylimidazol-1-yl group at the 6-position. Its molecular formula is C8H7ClN4 and its molecular weight is approximately 194.62 g/mol.
The compound belongs to the class of aryl chlorides and diazine derivatives. The electrophilic chlorine atom on the pyridazine ring renders the molecule amenable to a broad range of transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) as well as nucleophilic aromatic substitution (SNAr), while the imidazolyl moiety provides additional nitrogen coordination sites useful in target binding and further derivatization.
Key Chemical Properties and Handling
The compound is typically encountered as a solid at room temperature. As with most chloroheterocyclic intermediates, it should be handled with standard laboratory precautions: use appropriate personal protective equipment (PPE) including gloves, safety glasses, and a laboratory coat. Work in a well-ventilated area or fume hood to minimise inhalation exposure.
The reactive C–Cl bond, while stable under ambient conditions, can hydrolyse slowly in the presence of prolonged moisture exposure, so minimising contact with water during handling is advised. Always consult the Safety Data Sheet (SDS) supplied with the product for full hazard information before use.
Storage Recommendations
For optimal long-term stability, store 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine in a tightly sealed container under cool, dry conditions, away from light, oxidising agents, and moisture. Many chloroheterocyclic compounds are routinely stored at 2–8 °C or at room temperature under inert atmosphere depending on the supplier's specific recommendations.
Always verify the exact storage conditions printed on the product label or certificate of analysis (CoA) for SKU C188454, as Aladdin Scientific provides lot-specific stability data. Ensure the container is purged with inert gas (nitrogen or argon) before resealing after partial use to prevent degradation.
Applications in Research and Drug Discovery
The pyridazine scaffold is well represented in bioactive molecules and approved pharmaceuticals, particularly in kinase inhibitors and CNS-targeted agents. The chloro leaving group at the 3-position of 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine enables efficient library synthesis through palladium-catalysed coupling or SNAr displacement with amines, thiols, and alkoxides, allowing rapid generation of diverse analogues.
The 4-methylimidazolyl group itself is pharmacophorically relevant; imidazole-containing fragments are found in numerous drug candidates targeting histamine receptors, kinases, and metalloenzymes. Together, these features make the compound a strategic building block for fragment-based drug design and lead optimisation programmes.
Ordering, Purity, and Quality Assurance
3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine is available from Aladdin Scientific under SKU C188454. Customers are encouraged to request the Certificate of Analysis (CoA) for their specific lot to confirm purity, analytical data (typically HPLC, NMR, and/or MS), and physical characteristics before use in sensitive assays.
For bulk quantities, custom synthesis requirements, or questions about specific purity grades, please contact Aladdin Scientific's technical support or sales team. Orders can be placed through the Aladdin Scientific website or through authorised distributors. Registered account holders may also access loyalty points and promotional pricing — see the Rewards section of your account portal for details.
Frequently asked questions
What is the molecular formula and molecular weight of 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine?
The molecular formula of 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine is C8H7ClN4 and its molecular weight is approximately 194.62 g/mol. These values should be confirmed against the lot-specific Certificate of Analysis (CoA) provided by Aladdin Scientific.
What reactions can be performed using the chloro group of this compound?
The C–Cl bond at the 3-position of the pyridazine ring is highly versatile: it participates in palladium-catalysed cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings, as well as nucleophilic aromatic substitution (SNAr) with amines, thiols, and alkoxides. This makes the compound an efficient starting point for building diverse compound libraries in medicinal chemistry.
How should 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine be stored to maintain stability?
The compound should be stored in a tightly sealed container under cool, dry, and dark conditions, away from moisture and oxidising agents. It is advisable to back-fill the container with an inert gas such as nitrogen or argon after each use. Always refer to the product label and CoA for lot-specific storage temperature recommendations.
What safety precautions should I observe when handling this compound?
Standard laboratory safety practices apply: wear appropriate PPE including nitrile gloves, safety glasses, and a laboratory coat. Handle the compound in a well-ventilated area or fume hood. Avoid inhalation of dust or vapours and prevent skin and eye contact. Consult the Safety Data Sheet (SDS) for SKU C188454 for comprehensive hazard and first-aid information before use.
How can I order 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine from Aladdin Scientific?
You can order SKU C188454 directly through the Aladdin Scientific website by searching for the product name or SKU number. Orders can also be placed via authorised distributors. For bulk purchases, custom purity grades, or technical enquiries, please contact the Aladdin Scientific sales or technical support team directly.
References
- Aladdin Scientific product page for 3-Chloro-6-(4-methyl-1H-imidazol-1-yl)pyridazine, SKU C188454.
- General reference on pyridazine chemistry and its role in medicinal chemistry — textbook-level knowledge; specific citation to be confirmed.
- General reference on imidazole-containing pharmacophores in drug discovery — textbook-level knowledge; specific citation to be confirmed.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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