What Is 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide?

3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide (Aladdin SKU: C190237) is a synthetic organic compound belonging to the arylsulfonamide class. Its structure incorporates three pharmacophoric elements on a benzene ring: a cyano group (–CN) at the 3-position, a fluorine atom at the 4-position, and a sulfonamide linkage (–SO₂NH–) connecting the ring to a thiazol-2-yl moiety.

The combination of an electron-withdrawing cyano group, a fluorine substituent, and the biologically relevant thiazole ring makes this compound an attractive building block for the synthesis of biologically active molecules. Sulfonamide derivatives bearing heterocyclic substituents are widely explored in medicinal chemistry due to the pharmacological importance of the sulfonamide motif and the thiazole scaffold.

Key Chemical Properties and Handling

As an arylsulfonamide, this compound contains both electron-withdrawing groups (–CN, –F, –SO₂–) and a nucleophilic nitrogen, giving it moderate reactivity under standard synthetic conditions. The cyano group can be further elaborated via hydrolysis to a carboxylic acid or amide, or via cycloaddition chemistry, offering synthetic versatility.

The fluorine substituent at the 4-position activates the aromatic ring toward nucleophilic aromatic substitution (SNAr) at that position, which may be exploited in further derivatization. Researchers should handle this compound in a well-ventilated fume hood, wearing appropriate personal protective equipment (gloves, lab coat, and eye protection) in accordance with standard laboratory safety practices for fine chemicals.

No specific highly acute hazard data is included in the supplied source material; consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use.

Storage and Stability Guidelines

To maintain the integrity and purity of 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide, store the compound in a tightly sealed container in a cool, dry location away from direct light and moisture. Exposure to moisture may, over extended periods, risk slow hydrolysis of the sulfonamide linkage, a general concern for this compound class.

After each use, promptly reseal the container and return it to appropriate storage conditions. If long-term storage is required, consider storage under an inert atmosphere (e.g., nitrogen or argon). Always check the Certificate of Analysis (CoA) accompanying the specific lot for confirmed purity data and any lot-specific storage recommendations.

Ordering and Availability from Aladdin Scientific

3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide is available from Aladdin Scientific under SKU C190237. To place an order, researchers and procurement staff may visit the Aladdin Scientific website (aladdin-e.com), search by product name or SKU, and proceed through the standard online ordering workflow.

For bulk quantities, custom packaging, or institutional pricing inquiries, please contact Aladdin Scientific customer service directly. A Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are available upon request or can be downloaded from the product page on the website. Reward points, promotional codes, and institutional credit lines may be applied at checkout where applicable.

Reagent Specifications, Grade, and Purity

Aladdin Scientific supplies research-grade reagents intended for laboratory and R&D use. For 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide (C190237), specific purity data and analytical specifications (e.g., HPLC purity, NMR confirmation) are detailed on the product's Certificate of Analysis (CoA), which is lot-specific.

Researchers requiring material for GMP or regulated applications should contact Aladdin Scientific to discuss appropriate grade options and documentation. For standard research applications, the reagent-grade material is suitable for use as a synthetic building block or reference standard in non-regulated laboratory settings.