4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine FAQ
4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine FAQ
4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is a synthetic heterocyclic small molecule featuring a 2-aminothiazole core substituted with a 4-chlorothiophen-2-yl group at C-4 and a 4-cyclohexylpiperazin-1-yl group at C-5, making it a structurally complex research reagent of interest in medicinal chemistry and drug discovery programs.
- Chemical Name
- 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
- Aladdin SKU
- C953365B
- Core Scaffold
- 2-Aminothiazole
- Key Substituents
- 4-Chlorothiophen-2-yl at C-4; 4-cyclohexylpiperazin-1-yl at C-5
- Compound Class
- Synthetic heterocyclic small molecule
- Primary Application
- Medicinal chemistry and drug discovery research
Compound Overview and Structural Features
4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (Aladdin SKU: C953365B) is a fully synthetic, heterocyclic small molecule built upon a 2-aminothiazole scaffold. The thiazole ring is a five-membered aromatic heterocycle containing both sulfur and nitrogen atoms, and the 2-amino substitution is a pharmacophoric feature commonly associated with kinase inhibitor and antimicrobial pharmacology.
At the C-4 position, a 4-chlorothiophen-2-yl group is attached, introducing a second sulfur-containing heterocycle along with a halogen substituent that can modulate electronic properties, lipophilicity, and metabolic stability. At the C-5 position, a 4-cyclohexylpiperazin-1-yl group is present, conferring conformational rigidity via the cyclohexyl ring and providing a basic nitrogen centre through the piperazine moiety. This combination of structural elements gives the molecule a rich pharmacophoric profile relevant to structure–activity relationship (SAR) studies.
Physical Properties and Storage Recommendations
As a multi-ring heterocyclic compound bearing both sulfur atoms and a basic piperazine nitrogen, 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is expected to be a solid at room temperature. The presence of the chloro substituent and the lipophilic cyclohexyl group contribute to moderate-to-high lipophilicity, which typically limits aqueous solubility. Researchers should prepare stock solutions in dimethyl sulfoxide (DMSO) or dimethylformamide (DMF) and dilute into aqueous buffers immediately before use.
For long-term storage, the compound should be kept in a tightly sealed container away from light and moisture at –20 °C or as directed on the product datasheet. Repeated freeze–thaw cycles should be avoided by preparing single-use aliquots. Always consult the current Aladdin Scientific Certificate of Analysis (CoA) for confirmed purity, melting point, and other lot-specific data, as specific numerical values vary by lot.
Handling, Safety, and Regulatory Considerations
Although 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is supplied as a research reagent and not classified as a controlled substance under standard international schedules, standard laboratory safety precautions must be observed. Researchers should wear appropriate personal protective equipment (PPE) including nitrile gloves, lab coat, and safety goggles when handling the compound in powder or solution form.
The compound contains an organochlorine moiety and should be treated as potentially irritating to skin, eyes, and mucous membranes until definitive toxicological data are available. Waste disposal must comply with all applicable local and national regulations for chemical waste. Always refer to the Safety Data Sheet (SDS) supplied by Aladdin Scientific before use. The SDS is available on the product page or upon request from customer service.
Applications in Research
The 2-aminothiazole scaffold is a privileged structure in medicinal chemistry, appearing in numerous bioactive compounds with reported activity against kinases, ion channels, and microbial targets. The structural combination present in 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine — namely the aminothiazole core, the chlorothiophene ring, and the cyclohexylpiperazine side chain — is representative of compound classes explored in drug discovery campaigns targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
Researchers may employ this compound in biochemical binding assays, cell-based screening, or as a synthetic intermediate for generating analogue libraries. Its utility as a reference standard or tool compound in SAR studies should be validated experimentally within the specific biological context of each research programme. Aladdin Scientific supplies this compound for research use only; it is not intended for diagnostic, therapeutic, or veterinary use.
Ordering and Technical Support
4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is available from Aladdin Scientific under SKU C953365B. To place an order, visit the product page on the Aladdin Scientific website, add the desired quantity to your cart, and proceed through the standard checkout process. Bulk quantities, custom packaging, or custom synthesis enquiries can be directed to the Aladdin Scientific sales team via the contact form or by email.
For technical questions regarding solubility, formulation, analytical data, or application-specific guidance, please contact Aladdin Scientific technical support. The Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for each lot are available for download from the product page. For questions about order status, shipping, returns, or invoicing, please refer to the Help and Customer Service section of the Aladdin Scientific website.
Frequently asked questions
What is the recommended solvent for preparing a stock solution of C953365B?
Due to the compound's expected moderate-to-high lipophilicity arising from the cyclohexyl and chlorothiophenyl groups, DMSO is the most commonly recommended solvent for preparing concentrated stock solutions of heterocyclic small molecules of this type. The stock solution should be diluted into the appropriate aqueous buffer or cell culture medium immediately before use. Always verify solubility experimentally at your target concentration, as solubility can vary with lot and formulation conditions.
How should 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine be stored to maintain stability?
The compound should be stored as a solid in a tightly sealed, light-protected container at –20 °C to maximise shelf life. Moisture and repeated freeze–thaw cycles should be avoided; it is advisable to prepare single-use aliquots of stock solutions. Please refer to the lot-specific Certificate of Analysis and Safety Data Sheet available from Aladdin Scientific for confirmed storage conditions.
Is C953365B suitable for in vivo studies or clinical use?
No. 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (SKU C953365B) is supplied by Aladdin Scientific strictly for in vitro research purposes. It is not approved, tested, or intended for use in humans or animals as a therapeutic, diagnostic, or veterinary agent. Researchers considering any in vivo application must independently assess safety, purity requirements, and applicable regulatory frameworks.
What biological targets or assays is this compound most commonly associated with?
The 2-aminothiazole scaffold is a privileged medicinal chemistry motif associated with activity at kinase, ion channel, and microbial targets in the published literature. The specific chlorothiophenyl and cyclohexylpiperazinyl substituents present in C953365B are structural features explored in CNS, anti-infective, and oncology drug discovery. However, no specific biological activity data for this exact compound are cited in the current source material; researchers should conduct their own pharmacological profiling.
How do I obtain the Certificate of Analysis or Safety Data Sheet for C953365B?
The Certificate of Analysis (CoA) and Safety Data Sheet (SDS) for SKU C953365B are available for download directly from the product page on the Aladdin Scientific website. If you cannot locate the documents online, please contact Aladdin Scientific customer service with your lot number and they will provide the relevant documentation promptly.
References
- Aladdin Scientific product page for C953365B: 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine.
- Lombardino J G, Lowe J A. The role of the medicinal chemist in drug discovery — then and now. Nature Reviews Drug Discovery, 2004.
- Mederski W W K R et al. Aminothiazoles as privileged scaffolds in drug discovery. (General textbook-level reference — specific article title and authors require verification.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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