Compound Overview

4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine (SKU: C953365) is a synthetic heterocyclic compound built on a 2-aminothiazole scaffold. The thiazole ring bears a 4-chlorothiophen-2-yl group at the 4-position and a 4-cyclohexylpiperazin-1-yl group at the 5-position. The combination of the electron-rich aminothiazole core with a lipophilic cyclohexylpiperazine side chain and a halogenated thiophene ring makes this compound of interest in medicinal chemistry research as a building block or screening candidate. It is supplied by Aladdin Scientific for research purposes only and is not intended for clinical, diagnostic, or therapeutic use.

Safety and Handling Precautions

Prior to working with this compound, consult the Safety Data Sheet (SDS) provided by Aladdin Scientific. As a general precaution for research-grade heterocyclic amines and chlorinated aromatic compounds, observe the following guidelines:

• Wear appropriate personal protective equipment (PPE): laboratory coat, chemically resistant gloves, and safety eyewear.
• Handle in a well-ventilated fume hood to avoid inhalation of dust or vapors.
• Avoid contact with skin, eyes, and mucous membranes.
• Store according to the label instructions, typically in a cool, dry, well-ventilated area away from incompatible materials (strong oxidizers, strong acids/bases).
• Dispose of waste in accordance with local, regional, and national regulations.

Note: Specific hazard data for this compound are not fully established in the public literature; exercise caution and treat as a potentially hazardous research chemical.

Preparation and Storage Protocol

Solubility: Specific solubility data for C953365 are not confirmed in the source material. Based on the structural features of 2-aminothiazoles bearing a piperazine substituent, dissolution in dimethyl sulfoxide (DMSO) is a common starting point for preparing stock solutions of structurally similar compounds. Always verify solubility empirically before use.

Recommended preparation steps:

1. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation on the powder.
2. Prepare a stock solution by dissolving the compound in an appropriate anhydrous solvent (e.g., DMSO) at the desired concentration. Vortex or sonicate gently until fully dissolved.
3. For aqueous assay systems, dilute the DMSO stock with the aqueous buffer immediately before use; keep the final DMSO concentration ≤0.1% (v/v) unless otherwise validated for the assay.
4. Aliquot the stock solution into single-use volumes to minimize freeze–thaw cycles.

Storage: Store as directed on the product label. In the absence of specific instructions, short-term storage at −20 °C under inert gas (argon or nitrogen) in amber vials is recommended to protect against light, moisture, and oxidation. Confirm stability with the SDS or contact Aladdin Scientific technical support.

Potential Research Applications

The 2-aminothiazole scaffold is a privileged structure in medicinal chemistry, appearing in a range of bioactive compounds. The structural features of 4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine suggest potential utility in the following research contexts:

• Medicinal chemistry screening: As a building block or hit compound in structure–activity relationship (SAR) studies targeting kinases, receptors, or other protein families known to bind aminothiazole-containing ligands.
• Chemical biology: Probe development for investigating cellular signaling pathways.
• Synthetic chemistry: Intermediate or reference standard in the synthesis of more complex heterocyclic architectures.

Disclaimer: No specific biological activity or target has been confirmed for C953365 in the source material. Researchers should perform their own validation experiments. This compound is for research use only.

Quality, Ordering, and Technical Support

4-(4-Chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine is available from Aladdin Scientific under SKU C953365. To order or request a certificate of analysis (CoA), purity data, or additional technical documentation, please contact Aladdin Scientific directly through the website or your regional distributor.

For questions regarding solubility, stability, custom synthesis, or bulk quantities, reach out to Aladdin Scientific technical support. Always cite the SKU (C953365) when making inquiries to ensure accurate product identification.