Chemical Structure and Key Properties

4-(4-Methyl-1-piperazinyl)butanoic acid (CAS B690832) features a four-carbon alkyl chain that bridges a terminal carboxylic acid group to the nitrogen atom of an N-methylpiperazine ring. This structural arrangement provides two distinct reactive sites: (1) the carboxylic acid, which can be activated toward amide bond formation, ester coupling, or other acylation reactions; and (2) the piperazine nitrogens, which can coordinate to metals or engage in further N-alkylation chemistry.

The compound is a zwitterionic-capable molecule at physiological pH, given the basic piperazine moiety (predicted pKa of tertiary amine typically ~8–9) and the acidic carboxylate. This amphoteric character influences solubility and formulation behavior in aqueous media, making it relevant to prodrug design and water-soluble linker strategies.

Note: Specific physicochemical values such as exact melting point, logP, and pKa have not been confirmed from the supplier source material and should be verified against the Certificate of Analysis or peer-reviewed databases prior to use in publications.

Research and Synthetic Applications

The N-methylpiperazine motif is one of the most frequently encountered pharmacophoric fragments in approved drugs and clinical candidates. Its inclusion in a molecule generally improves aqueous solubility, modulates membrane permeability, and can reduce protein binding—all desirable attributes in lead optimization. By tethering this motif to a butanoic acid spacer, 4-(4-Methyl-1-piperazinyl)butanoic acid offers a pre-assembled, commercially available fragment that researchers can directly incorporate into target structures without multi-step de novo synthesis.

Key application areas include:

• Amide coupling: Activation of the carboxylic acid with coupling agents (e.g., EDC/HOBt, HATU) to form stable amide bonds with amine-bearing scaffolds.
• Prodrug linkers: The flexible butanoic acid spacer can be used to modulate the release kinetics of prodrug conjugates.
• PROTAC and bifunctional molecule design: The compound can serve as a solubilizing linker element between a warhead and an E3 ligase ligand.
• Coordination chemistry: The piperazine nitrogens can act as donor atoms in metal–organic frameworks or catalytic complexes.

Review flag: Specific literature examples citing this exact compound in PROTAC or prodrug applications have not been sourced from the provided material and require independent verification.

Handling, Storage, and Safety Considerations

As with all fine chemical reagents, 4-(4-Methyl-1-piperazinyl)butanoic acid should be handled following standard laboratory safety protocols. General guidance includes:

• Personal protective equipment: Wear nitrile gloves, safety glasses, and a lab coat when weighing or transferring the compound.
• Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area away from strong oxidizers and acids. Specific recommended storage temperature should be confirmed on the product label or Certificate of Analysis supplied with SKU B690832.
• Disposal: Dispose of in accordance with local environmental regulations for nitrogen-containing organic compounds.

Researchers should consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for SKU B690832 for comprehensive hazard classification, first-aid measures, and regulatory information before use.

Review flag: Exact GHS hazard classifications and specific storage temperature for B690832 are not confirmed in the source material; retrieve from the official SDS before publication.

Ordering and Availability

4-(4-Methyl-1-piperazinyl)butanoic acid is available from Aladdin Scientific under SKU B690832. Researchers and procurement teams can place orders through the Aladdin Scientific online catalog or by contacting a regional sales representative. When ordering, confirm the required pack size, purity grade, and any lot-specific analytical data (e.g., HPLC purity, NMR confirmation) to ensure suitability for your application.

For bulk quantities or custom synthesis inquiries, Aladdin Scientific's custom chemistry services team can be contacted directly. Lead times and pricing are subject to stock availability; consult the current online catalog for up-to-date pricing and promotional offers.