Chemical Identity and Structure

4-Acetamido-1-benzylpiperidine (Aladdin SKU: A151609) is a substituted piperidine compound featuring two key functional groups: a tertiary amine formed by N-benzylation of the piperidine nitrogen, and a secondary amide (acetamido) group at the 4-position of the ring. The benzyl group on nitrogen renders the tertiary amine relatively non-nucleophilic under mild conditions, while the acetamido moiety at the 4-position provides a hydrogen-bond donor/acceptor site commonly exploited in drug–target interactions. The piperidine scaffold itself is one of the most prevalent ring systems found in approved pharmaceuticals, making functionalized derivatives such as this compound valuable starting materials or intermediates in drug discovery programs.

Recommended Storage and Handling

As with most piperidine amide derivatives, 4-Acetamido-1-benzylpiperidine should be stored in a tightly sealed container away from moisture, light, and heat. A cool, dry environment (typically 2–8 °C or as specified on the product Certificate of Analysis) is recommended to maintain long-term stability. When handling the compound, standard laboratory personal protective equipment (PPE) — including nitrile gloves, safety glasses, and a lab coat — should be worn. Work in a well-ventilated area or fume hood is advised. Always consult the Safety Data Sheet (SDS) provided by Aladdin Scientific before use, as it contains the most current hazard classification, first-aid measures, and disposal guidance specific to this material.

Note: Specific GHS hazard classification, flash point, and LD50 values are not reproduced here; refer to the official Aladdin SDS for A151609 for authoritative safety data.

Research and Synthetic Applications

4-Acetamido-1-benzylpiperidine serves primarily as a versatile building block and intermediate in organic synthesis and medicinal chemistry. Its utility stems from the orthogonal reactivity of its functional groups: the N-benzyl group can be selectively removed by hydrogenolysis (e.g., Pd/C, H₂) to unmask the secondary piperidine amine for further elaboration, such as reductive amination, acylation, or sulfonylation. The acetamido group can participate in hydrogen bonding, influence conformational preferences of the ring, and serve as a handle for further chemical transformations after selective hydrolysis to the free amine. Such structural flexibility makes this compound particularly attractive in fragment-based drug discovery, SAR (structure–activity relationship) studies, and as a scaffold for generating libraries of piperidine-based analogues targeting GPCRs, ion channels, and enzyme active sites.

Purity, Quality, and Certificate of Analysis

Aladdin Scientific provides a Certificate of Analysis (CoA) with each lot of 4-Acetamido-1-benzylpiperidine (A151609). The CoA documents lot-specific purity data typically determined by techniques such as HPLC or GC, along with identity confirmation via NMR or MS. Researchers should request and review the CoA for their specific lot prior to use, particularly for applications where reagent purity is critical to experimental reproducibility, such as coupling reactions in multi-step synthesis or biological screening assays. For custom purity requirements or larger quantities, contact Aladdin Scientific's technical sales team for further options.

Ordering, Availability, and Support

4-Acetamido-1-benzylpiperidine is available from Aladdin Scientific under SKU A151609. Orders can be placed through the Aladdin Scientific website, via email, or through authorised distributors. Standard pack sizes are listed on the product page; custom quantities may be available upon request. Aladdin Scientific's technical support team is available to assist with questions regarding product specifications, compatibility with specific protocols, or bulk pricing. For regulatory or import documentation requirements, the customer service team can provide relevant compliance documents including the SDS and CoA upon request.