What Is 4-Bromo-8-(trifluoromethoxy)quinoline?

4-Bromo-8-(trifluoromethoxy)quinoline is a halogenated, fluorine-containing quinoline heterocycle. The quinoline core is a bicyclic aromatic system consisting of a benzene ring fused to a pyridine ring, and it is a privileged scaffold in medicinal chemistry due to its presence in numerous bioactive molecules and approved drugs.

Two key substituents define this compound's reactivity profile. The bromine atom at the 4-position serves as an electrophilic handle ideally suited for palladium-catalyzed cross-coupling reactions such as Suzuki–Miyaura, Buchwald–Hartwig, and Sonogashira couplings, enabling rapid diversification of the scaffold. The trifluoromethoxy (–OCF₃) group at the 8-position is a strongly electron-withdrawing moiety that modulates the electronic density of the ring, enhances lipophilicity (as measured by increased logP), and confers excellent metabolic stability—properties highly desirable in drug candidates.

Note: Molecular weight and exact CAS number should be verified against the current certificate of analysis provided with SKU B732558.

What Are the Main Applications of This Compound?

4-Bromo-8-(trifluoromethoxy)quinoline is primarily used as a synthetic building block in the following research areas:

• Medicinal Chemistry & Drug Discovery: The compound serves as a versatile intermediate for constructing quinoline-based pharmacophores. Researchers use it to introduce the –OCF₃ group and the quinoline nitrogen into candidate molecules, targeting receptors, kinases, and other enzymes where fluorinated quinolines have demonstrated biological activity.
• Cross-Coupling Chemistry: The C–Br bond at position 4 is highly reactive toward Pd(0)/Pd(II)-catalyzed coupling protocols, making this reagent valuable for building biaryl, heteroaryl, and aminoquinoline libraries.
• Agrochemical Research: Fluorinated heterocycles are well-established in crop-protection compound design, and this scaffold may serve as an intermediate in the synthesis of candidate agrochemicals.
• Materials Science: Quinoline derivatives with electron-withdrawing substituents are occasionally explored in organic electronics applications, though this is a secondary application area.

Specific literature citations for biological activity data should be verified independently; review flag raised.

How Should This Compound Be Handled and Stored Safely?

As with all halogenated and fluorinated organic reagents, appropriate laboratory safety practices are essential when working with 4-Bromo-8-(trifluoromethoxy)quinoline:

• Personal Protective Equipment (PPE): Wear chemical-resistant gloves, laboratory coat, and eye protection at all times. Work in a well-ventilated fume hood.
• Storage: Store the compound in a tightly sealed container in a cool, dry, and well-ventilated area, away from moisture, strong oxidizers, and strong bases. Specific temperature requirements should be confirmed on the Safety Data Sheet (SDS) for SKU B732558.
• Disposal: Dispose of waste in accordance with local, regional, and national regulations governing halogenated organic compounds.
• Spill Management: In the event of a spill, use appropriate absorbent material and dispose of as hazardous chemical waste. Avoid inhalation of dust or vapors.

Always consult the current SDS provided by Aladdin Scientific for SKU B732558 before use. SDS content supersedes general guidance given here.

How to Order and What to Expect from Aladdin Scientific

4-Bromo-8-(trifluoromethoxy)quinoline is available from Aladdin Scientific under SKU B732558. To place an order or obtain a quotation:

• Visit the Aladdin Scientific website and search for SKU B732558 or the full product name.
• Select the required pack size and quantity, then proceed through the standard checkout process.
• For bulk orders, institutional accounts, or custom packaging inquiries, contact the Aladdin Scientific sales team directly.

Upon receipt, customers should inspect the package for integrity, verify the lot number and certificate of analysis (CoA), and confirm purity data before use in critical experiments. The CoA will include confirmed CAS number, purity (typically assessed by GC or HPLC), and appearance data.

For questions about pricing, promotions, shipping conditions, or returns, refer to the respective policy pages on the Aladdin Scientific website or contact customer service.