Chemical Identity and Physicochemical Properties

4-Methylmorpholin-3-one (also referred to as N-methylmorpholin-3-one) is a six-membered heterocyclic lactam bearing both a nitrogen and an oxygen atom in the ring. Its molecular formula is C₅H₉NO₂ with a molecular weight of approximately 115.13 g/mol. The compound features an amide (lactam) carbonyl within the morpholine scaffold, which confers a degree of electrophilicity at the carbonyl carbon while the ring oxygen provides an additional heteroatom interaction site.

Key physicochemical characteristics to consider when planning experiments include its moderate polarity, which gives it good solubility in common polar aprotic and protic solvents such as dichloromethane, ethanol, and water. Researchers should verify specific melting point, boiling point, and solubility data from the certificate of analysis (CoA) supplied with each lot, as these values may vary slightly between batches.

Note: Precise physical constants (melting point, boiling point, density, refractive index) should be confirmed against the product CoA or authoritative chemical databases such as Reaxys or SciFinder before use in critical applications.

Laboratory Applications and Synthetic Utility

4-Methylmorpholin-3-one serves primarily as a synthetic intermediate and building block in organic and medicinal chemistry. The lactam carbonyl is amenable to nucleophilic addition and ring-opening reactions under appropriate conditions, making this scaffold useful for the construction of more complex nitrogen- and oxygen-containing frameworks.

Potential application areas include:

• Building block in medicinal chemistry: The morpholinone ring is a recognized pharmacophore fragment encountered in bioactive molecule design. It may be incorporated into drug candidates to modulate lipophilicity and hydrogen-bonding capacity.
• Intermediate for heterocyclic synthesis: The compound can serve as a precursor to related morpholine derivatives through selective reduction, hydrolysis, or N- and O-functionalization reactions.
• Probe in structure–activity relationship (SAR) studies: Its well-defined ring geometry makes it suitable for SAR exploration in hit-to-lead campaigns.

Review flag: Specific published synthetic protocols employing 4-Methylmorpholin-3-one as a key reagent were not identified in the source material. Users should conduct a primary literature search (e.g., SciFinder, Reaxys) to identify validated procedures before use.

Safe Handling, Storage, and Waste Disposal

As with all laboratory reagents, appropriate safety precautions must be observed when handling 4-Methylmorpholin-3-one. Researchers should consult the Safety Data Sheet (SDS) for the specific lot purchased from Aladdin Scientific before beginning any work.

Personal Protective Equipment (PPE): Wear chemical-resistant gloves (e.g., nitrile), safety goggles, and a laboratory coat. Work in a well-ventilated fume hood when weighing or transferring the compound to minimise inhalation exposure.

Storage: Store in a tightly closed container in a cool, dry, and well-ventilated area, away from strong oxidising agents, strong acids, and strong bases. Follow any specific temperature or humidity recommendations stated on the product label and CoA.

Spill management: In the event of a spill, avoid generating dust. Collect material using inert absorbent and dispose of in accordance with local, regional, and national regulations for chemical waste.

Waste disposal: Do not pour reagent down the drain. Segregate waste according to institutional guidelines and applicable environmental regulations.

Review flag: Detailed GHS hazard classifications and specific first-aid measures should be verified directly from the current SDS provided by Aladdin Scientific, as regulatory classifications can be updated.

Quality Assurance and Product Specifications

Aladdin Scientific supplies 4-Methylmorpholin-3-one (SKU: M725384) with a certificate of analysis (CoA) confirming lot-specific purity and key physicochemical parameters. Researchers are advised to:

• Request and review the CoA before use to confirm purity, appearance, and any residual solvent content relevant to their application.
• Perform additional in-house characterisation (e.g., NMR, HPLC) if the application demands ultra-high purity or if the reagent will be incorporated into a regulated assay or clinical research workflow.
• Check that the lot number on the container matches the CoA provided.

For procurement teams, the product is available under SKU M725384. Contact Aladdin Scientific technical support for bulk quantities, custom purity grades, or specific analytical data requirements.

Review flag: Specific purity grade percentages and analytical methods used for QC were not included in the provided source material. These should be confirmed from the current product page or CoA on the Aladdin Scientific website.

Ordering Information and Technical Support

4-Methylmorpholin-3-one is available from Aladdin Scientific under the following catalogue information:

To place an order, visit the Aladdin Scientific website or contact your regional sales representative. For technical enquiries regarding applications, compatibility, or analytical data, the Aladdin Scientific technical support team is available to assist.

Bulk quantity pricing, custom packaging, and specialised purity grades may be available upon request. Lead times for non-stock configurations should be confirmed with the sales team at the time of enquiry.