Chemical Identity and Structure

5-Bromo-1,1,1-trifluoropentane (CAS 407-97-6; SKU B698162) is a linear five-carbon alkyl halide bearing a trifluoromethyl group at C-1 and a bromine leaving group at C-5. Its molecular formula is C₅H₈BrF₃ with a molecular weight of approximately 205.02 g/mol. The strong electron-withdrawing character of the CF₃ group imparts distinctive physicochemical properties, including elevated lipophilicity relative to the non-fluorinated analogue and metabolic stability relevant to pharmaceutical design. The primary alkyl bromide moiety at the opposite terminus provides a readily accessible electrophilic site for nucleophilic substitution (S_N2) reactions.

Synthetic Applications

5-Bromo-1,1,1-trifluoropentane serves as a versatile electrophilic fluorinated linker in modern organic synthesis. Its primary alkyl bromide reacts efficiently with a broad range of nucleophiles including amines, thiols, alcohols, malonates, and organometallic species, allowing the introduction of a four-methylene trifluoromethyl chain into complex molecules. This makes it particularly valuable in:

• Medicinal chemistry: Installation of CF₃-terminated alkyl chains to modulate pharmacokinetic properties such as membrane permeability and metabolic resistance.
• Materials science: Synthesis of fluorinated polymers, surfactants, and liquid-crystal components requiring defined fluorocarbon segments.
• Agrochemical research: Preparation of fluorinated intermediates for bioactive molecule libraries.

The bifunctional nature of the molecule—electrophilic bromide plus electron-withdrawing CF₃—enables sequential derivatization strategies in multi-step synthesis programs.

Safety and Handling Guidelines

As with all low-molecular-weight alkyl bromides, 5-Bromo-1,1,1-trifluoropentane should be handled with appropriate laboratory precautions:

• Personal protective equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, and a laboratory coat are recommended. Work in a well-ventilated fume hood.
• Storage: Store in a tightly sealed container under inert atmosphere (nitrogen or argon) in a cool, dry location away from strong oxidizers, bases, and ignition sources. Refrigerated storage (2–8 °C) is advisable to maintain long-term stability.
• Waste disposal: Dispose of as halogenated organic waste in accordance with local institutional and governmental regulations.
• First aid: In case of skin or eye contact, flush immediately with copious water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air.

Consult the Safety Data Sheet (SDS) supplied by Aladdin Scientific for complete hazard, transport, and regulatory information before use.

Reagent Specifications and Quality

Aladdin Scientific offers 5-Bromo-1,1,1-trifluoropentane (SKU B698162) as a research-grade reagent. Researchers and procurement officers should note the following when evaluating suitability:

• Purity: Research-grade material is typically analyzed by GC and/or NMR. Confirm the certificate of analysis (CoA) for the specific lot before use in sensitive applications.
• Packaging: Available in multiple quantities to suit exploratory screening through scale-up synthesis. Contact Aladdin Scientific for bulk pricing and custom pack sizes.
• Lot traceability: Each shipment is accompanied by a CoA detailing purity, appearance, and analytical data for full traceability in regulated environments.

For the most current specifications, availability, and pricing, refer to the Aladdin Scientific product page for SKU B698162.