What Is 5-Butyl-3-p-tolyl-1,2,4-oxadiazole?

5-Butyl-3-p-tolyl-1,2,4-oxadiazole (Aladdin SKU: B178907) is a fully synthetic, small-molecule heterocyclic compound built around the 1,2,4-oxadiazole ring system. The 1,2,4-oxadiazole scaffold is a five-membered aromatic ring containing one oxygen atom and two nitrogen atoms at the 1, 2, and 4 positions. In this particular compound, a linear butyl chain is appended at the 5-position and a para-tolyl (4-methylphenyl) aryl group is attached at the 3-position.

The combination of an electron-rich aromatic substituent with an aliphatic chain confers a balanced lipophilicity profile that is of broad interest in drug discovery programs. The 1,2,4-oxadiazole ring is bioisosteric with ester and amide functional groups, a property frequently exploited to improve metabolic stability of candidate molecules.

Key Chemical Properties and Structural Features

The 1,2,4-oxadiazole ring system is aromatic and relatively electron-deficient compared to simple furan, owing to the two nitrogen atoms. This makes the ring resistant to nucleophilic attack under mild conditions and contributes to the overall chemical stability of the compound. The para-methyl group on the tolyl substituent at C-3 provides a slight electron-donating inductive effect, while the butyl chain at C-5 primarily influences physical properties such as solubility and lipophilicity (logP).

Researchers should note that 1,2,4-oxadiazoles are generally considered metabolically more stable than their corresponding amide or ester analogues, which is one reason this scaffold appears frequently in bioactive compound libraries and drug candidate optimization campaigns.

Note: Specific physicochemical data such as exact molecular weight, melting point, and measured logP for B178907 should be confirmed from the current Aladdin product specification sheet, as these values are subject to lot-specific analytical results.

Handling, Storage, and Safety Guidelines

As with all synthetic organic reagents, standard laboratory safety precautions should be observed when working with 5-Butyl-3-p-tolyl-1,2,4-oxadiazole. Users should consult the current Safety Data Sheet (SDS) provided by Aladdin Scientific before use. General guidance includes:

• Personal Protective Equipment: Wear appropriate gloves, safety goggles, and a lab coat. Work in a well-ventilated area or fume hood.
• Storage: Store the compound in a tightly sealed container in a cool, dry location away from incompatible materials, moisture, and light. Specific storage temperature recommendations should be confirmed from the product label and SDS.
• Disposal: Dispose of waste material in accordance with local, regional, and national regulations governing the disposal of chemical waste.

Important: Always verify hazard classifications, GHS pictograms, and first-aid measures in the official SDS for lot B178907, as these supersede any general guidance provided here.

Research and Synthetic Chemistry Applications

5-Butyl-3-p-tolyl-1,2,4-oxadiazole serves primarily as a reference compound or synthetic building block in research settings. Key areas of application include:

• Medicinal Chemistry: The 1,2,4-oxadiazole scaffold is a recognized pharmacophore element found in several approved drugs and clinical candidates. This compound can serve as a structural analogue or fragment for SAR (structure–activity relationship) studies.
• Bioisosteric Replacement Studies: Researchers investigating the replacement of metabolically labile ester or amide bonds with more stable oxadiazole bioisosteres may use this compound as a reference standard.
• Heterocyclic Synthesis: It can be employed as a starting material or intermediate in the preparation of more complex oxadiazole-containing molecules.
• Physical Property Benchmarking: The defined substitution pattern (aryl at C-3, alkyl at C-5) makes B178907 useful for benchmarking solubility, permeability, and logP measurements within a compound series.

Researchers are encouraged to search the primary literature for specific biological assay data relevant to their intended application, as Aladdin Scientific does not guarantee biological activity for this compound.

Ordering, Purity, and Quality Information

5-Butyl-3-p-tolyl-1,2,4-oxadiazole is available from Aladdin Scientific under SKU B178907. When placing an order or evaluating the product for your research, consider the following:

• Purity: Purity grade and analytical data (e.g., HPLC purity, NMR confirmation) are provided on the Certificate of Analysis (CoA) for each lot. Request the CoA from your Aladdin account representative or download it from the product page.
• Available Pack Sizes: Please refer to the current product listing on the Aladdin Scientific website for available quantities and pricing, as these are subject to change.
• Lead Time: Standard stock availability and lead times are indicated on the product page. Contact customer service for urgent requirements or bulk inquiries.
• Custom Synthesis: For quantities or purity grades not listed, Aladdin Scientific's custom synthesis team may be able to accommodate specific requirements — contact us for a quotation.

For procurement questions, volume discounts, or institutional account setup, please contact Aladdin Scientific customer service directly.