Chemical Identity and Structure

5-Chloro-2-(methanesulfonamido)benzoic acid (CAS number subject to verification; Aladdin SKU C728872) is an aromatic compound bearing three distinct functional groups on a benzene ring: a carboxylic acid at position 1, a methanesulfonamido (–NH–SO₂CH₃) group at position 2, and a chlorine substituent at position 5. Its molecular formula is C₈H₈ClNO₄S, giving a molecular weight of approximately 249.67 g/mol.

The combination of an electron-withdrawing chloro group and a sulfonamide linkage adjacent to the carboxylic acid makes this compound a versatile scaffold for medicinal chemistry, enabling further derivatization through amide coupling, esterification, or N-alkylation reactions.

Physicochemical Properties and Handling

This compound is typically obtained as a white to off-white crystalline or powdered solid. As with most sulfonamide-carboxylic acid derivatives, it should be handled with standard laboratory precautions: wear appropriate personal protective equipment (gloves, lab coat, safety goggles), and work in a well-ventilated area or fume hood.

Solubility: the compound is expected to show moderate solubility in polar aprotic solvents such as DMSO and DMF, and limited solubility in water at neutral pH; solubility in water may improve under basic conditions due to ionization of the carboxylic acid group. Researchers should confirm solubility experimentally for their specific application conditions.

Stability: store in a tightly sealed container in a cool, dry location away from light and moisture. Avoid contact with strong oxidizing agents, strong bases, and reactive amines.

Applications in Research and Synthesis

5-Chloro-2-(methanesulfonamido)benzoic acid serves primarily as a synthetic intermediate and building block in medicinal chemistry and pharmaceutical research. The carboxylic acid group allows straightforward conversion to amides, esters, and acyl halides, while the sulfonamide nitrogen can be further alkylated or acylated under appropriate conditions. The aryl chloride at the 5-position is amenable to transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling rapid library synthesis.

Compounds of this structural class are of interest in drug discovery programs targeting a variety of biological pathways; however, researchers should consult the primary literature for specific biological activity data, as Aladdin Scientific supplies this compound for research use only.

Purity, Specifications and Quality

Aladdin Scientific offers 5-Chloro-2-(methanesulfonamido)benzoic acid under catalog number C728872. Specific purity grades, lot-level certificates of analysis (CoA), and analytical data (e.g., HPLC purity, NMR, MS confirmation) are available upon request or via the product page on the Aladdin Scientific website.

Researchers requiring high-purity material for biological assays or regulatory-filing purposes should request the relevant CoA and confirm that the stated purity meets their application requirements before use. Contact Aladdin Scientific technical support for custom quantity or purity inquiries.

Ordering, Storage and Regulatory Information

Ordering: 5-Chloro-2-(methanesulfonamido)benzoic acid (SKU C728872) can be ordered directly through the Aladdin Scientific website, by email, or via authorized distributors. Bulk quantities may be available; contact our sales team for pricing and lead times.

Storage: Upon receipt, store the compound according to the label instructions — typically at room temperature or 2–8 °C in a sealed, moisture-proof container, away from direct light. Always check the product label and CoA for lot-specific storage recommendations.

Regulatory: This product is supplied for research use only and is not intended for diagnostic, therapeutic, or food use. Exportation may be subject to local regulations; buyers are responsible for compliance with applicable laws. Safety data sheet (SDS) is available on request.