6-Chloro-1H-Indazole-4-Carboxylic Acid: Key FAQs
6-Chloro-1H-Indazole-4-Carboxylic Acid: Key FAQs
6-Chloro-1H-indazole-4-carboxylic acid is a chlorine-substituted indazole heterocyclic compound widely used as a synthetic building block in medicinal chemistry and pharmaceutical research.
- Product SKU
- C731310
- Chemical Name
- 6-Chloro-1H-indazole-4-carboxylic acid
- Core Scaffold
- 1H-Indazole (bicyclic nitrogen-containing heterocycle)
- Key Functional Groups
- Carboxylic acid (–COOH) at C-4; chloro substituent (–Cl) at C-6
- Typical Application
- Pharmaceutical intermediate and building block for heterocyclic synthesis
- Supplier
- Aladdin Scientific
What Is 6-Chloro-1H-Indazole-4-Carboxylic Acid?
6-Chloro-1H-indazole-4-carboxylic acid (SKU: C731310) is a halogenated indazole derivative bearing a carboxylic acid group at the 4-position and a chlorine atom at the 6-position of the indazole ring system. The indazole scaffold is a bicyclic heteroaromatic structure composed of a benzene ring fused to a pyrazole ring, and is a privileged structural motif in drug discovery due to its ability to interact with a wide range of biological targets. The presence of the carboxylic acid group provides a versatile handle for further chemical transformations, including amide coupling, esterification, and metal-catalyzed cross-coupling reactions after appropriate activation. The chloro substituent further extends synthetic utility by enabling nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions.
How Should I Store and Handle This Compound?
As with most indazole carboxylic acid derivatives, 6-Chloro-1H-indazole-4-carboxylic acid should be stored in a cool, dry, and well-ventilated location, away from direct light and moisture. Sealed storage under an inert atmosphere (nitrogen or argon) is recommended to preserve chemical integrity over time. Standard laboratory safety precautions apply: wear appropriate personal protective equipment (PPE) including nitrile gloves, safety glasses, and a lab coat when handling this compound. Avoid inhalation of dust or aerosols. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for complete hazard information before use. This compound is intended for research use only and is not for human or veterinary diagnostic or therapeutic use.
What Are the Typical Research Applications?
6-Chloro-1H-indazole-4-carboxylic acid serves primarily as a synthetic building block in medicinal chemistry programs. Its bifunctional nature — combining a reactive carboxylic acid and a halogen substituent on a drug-relevant heterocyclic core — makes it valuable for constructing more complex target molecules. Common applications include: (1) preparation of amide or ester derivatives via reaction of the carboxylic acid with amines or alcohols; (2) palladium- or copper-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) exploiting the C-6 chloro group; and (3) use as a fragment or pharmacophore in structure-activity relationship (SAR) studies targeting kinases, GPCRs, or other enzymes where the indazole motif is known to be biologically relevant. Researchers in drug discovery, agrochemical research, and materials science may find utility in this compound.
How to Order and What to Expect from Aladdin Scientific
6-Chloro-1H-indazole-4-carboxylic acid is available from Aladdin Scientific under SKU C731310. Orders can be placed through the Aladdin Scientific website or by contacting your regional sales representative. Upon ordering, you will receive a product accompanied by a Certificate of Analysis (CoA) documenting lot-specific purity data. If you require a Safety Data Sheet (SDS), bulk quantities, or custom packaging, please contact Aladdin Scientific customer service directly. Aladdin Scientific's reward points, coupon, and credit programs may apply to eligible orders — consult the promotions section of the website or your account manager for current offers. Returns and refunds are handled in accordance with Aladdin Scientific's standard returns policy; please review those terms on the website before ordering.
Purity, Specifications and Quality Assurance
Aladdin Scientific supplies 6-Chloro-1H-indazole-4-carboxylic acid (C731310) as a research-grade reagent. Each lot is accompanied by a Certificate of Analysis (CoA) that reports purity as determined by appropriate analytical methods (typically HPLC and/or NMR). Researchers should review the CoA for the specific lot received to confirm suitability for their application. If you require a higher purity grade or additional analytical data (e.g., elemental analysis, mass spectrometry), please contact Aladdin Scientific technical support to discuss available options. Consistent quality and reliable lot-to-lot reproducibility are core commitments of Aladdin Scientific's reagent supply program.
Frequently asked questions
What is the CAS number for 6-Chloro-1H-indazole-4-carboxylic acid?
The CAS number for 6-Chloro-1H-indazole-4-carboxylic acid is not explicitly stated in the current source material. Please refer to the product page for SKU C731310 on the Aladdin Scientific website or the Certificate of Analysis for the verified CAS number.
What purity grade is available for C731310 from Aladdin Scientific?
6-Chloro-1H-indazole-4-carboxylic acid (C731310) is supplied as a research-grade reagent. Lot-specific purity data are provided in the Certificate of Analysis included with each shipment. Contact Aladdin Scientific customer service if a specific minimum purity is required for your application.
Can this compound be used directly in biological assays?
6-Chloro-1H-indazole-4-carboxylic acid is supplied for research use only and is not certified or validated for direct use in clinical or diagnostic assays. Researchers should perform their own suitability testing, including solubility and stability assessments in relevant assay buffers, before incorporating this compound into biological experiments.
How should I dissolve 6-Chloro-1H-indazole-4-carboxylic acid for use in reactions?
Indazole carboxylic acid derivatives are generally soluble in polar organic solvents such as DMSO, DMF, and methanol. Solubility in aqueous systems may require the addition of a base (e.g., sodium hydroxide or potassium carbonate) to deprotonate the carboxylic acid. Exact solubility data for this specific compound should be experimentally determined or sourced from the product CoA.
Are there related indazole building blocks available from Aladdin Scientific?
Aladdin Scientific offers a broad catalog of heterocyclic building blocks and pharmaceutical intermediates. For related indazole derivatives or structurally analogous compounds, please search the Aladdin Scientific product catalog online or contact your sales representative for recommendations.
References
- Aladdin Scientific product page for 6-Chloro-1H-indazole-4-carboxylic acid, SKU C731310.
- March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience. (General reference for carboxylic acid and halide reactivity in heterocyclic systems.)
- Joule, J. A.; Mills, K. Heterocyclic Chemistry. 5th ed. Wiley-Blackwell. (General reference for indazole chemistry.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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