6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine FAQs
6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine FAQs
6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1，3-diamine is a heterocyclic small molecule featuring a 2-aminothiazole core substituted with a pyridin-3-yl group and linked to a 2-amino-4-methylaniline moiety, available from Aladdin Scientific (SKU: M732089) as a research-grade chemical building block.
- Product Name
- 6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine
- SKU
- M732089
- Core Structural Features
- 2-Aminothiazole ring substituted at C-4 with pyridin-3-yl; N1 linked to a 6-methyl-1,3-diaminobenzene
- Compound Class
- Heterocyclic diamine; aminothiazole derivative
- Intended Use
- Research reagent and chemical building block for medicinal chemistry and synthetic applications
- Supplier
- Aladdin Scientific
What Is 6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine?
6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine (Aladdin SKU: M732089) is a synthetic heterocyclic organic compound. Its structure combines three pharmacophoric fragments: a 1,3-diaminobenzene unit bearing a 6-methyl substituent, a 2-aminothiazole linker, and a pyridin-3-yl group at the 4-position of the thiazole ring.
The 2-aminothiazole motif is widely recognised in medicinal chemistry as a privileged scaffold associated with a broad range of biological activities. The pyridine nitrogen and the multiple amino groups confer hydrogen-bond donor and acceptor capacity, making this compound a versatile building block for the synthesis of more complex drug-like molecules or for use as a probe compound in biochemical assays.
Physicochemical Properties and Structure
The compound contains a thiazole ring fused pharmacophore with nitrogen and sulfur heteroatoms, conferring distinct electronic and steric properties relative to purely carbocyclic analogues. The presence of two primary amine groups (the ring exocyclic amino group and the aniline amino group) and the pyridine nitrogen means the molecule possesses multiple sites capable of protonation and hydrogen bonding, which influences its solubility profile and reactivity.
As with many aminothiazole-containing compounds, solubility in polar aprotic solvents such as DMSO is generally expected to be higher than in water; researchers are advised to prepare fresh stock solutions and verify concentration by UV-Vis spectroscopy or an orthogonal analytical method. Specific physicochemical data (exact molecular weight, melting point, logP) should be confirmed from the certificate of analysis supplied with each lot.
Storage, Handling, and Safety
As a general guideline for aromatic amine-containing heterocyclic compounds, 6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine should be stored in a tightly sealed container, protected from light and moisture, at a cool and dry location (typically 2–8 °C or as specified on the product label). Long-term storage under inert atmosphere (nitrogen or argon) may help prevent oxidation of the amine functionalities.
Standard laboratory safety precautions apply: use appropriate personal protective equipment (lab coat, gloves, safety glasses), work in a well-ventilated area or fume hood, and avoid inhalation of dust or aerosols. Researchers should consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for hazard classification, first-aid measures, and disposal guidelines specific to this compound and applicable local regulations.
Ordering and Procurement from Aladdin Scientific
6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine is available from Aladdin Scientific under SKU M732089. Customers can place orders through the Aladdin Scientific website or by contacting customer service directly. A certificate of analysis (CoA) confirming purity and lot-specific analytical data is available upon request for each batch.
For bulk quantities, custom synthesis inquiries, or questions regarding availability and lead times, please contact the Aladdin Scientific sales or technical support team. Ensure that import/export regulations applicable to your institution and jurisdiction are reviewed prior to ordering.
Frequently asked questions
What is the chemical structure of 6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine?
The compound features a central 2-aminothiazole ring with a pyridin-3-yl group at the 4-position. The exocyclic amino group at C-2 of the thiazole is connected via a secondary amine linkage to a benzene ring that bears both a free amino group at the 3-position and a methyl group at the 6-position, forming the 6-methyl-1,3-diaminobenzene unit. Together these fragments create a multi-nitrogen heterocyclic scaffold with both hydrogen-bond donor and acceptor sites.
How should I dissolve and store stock solutions of M732089?
DMSO is generally recommended as the primary solvent for heterocyclic amines of this class due to their limited aqueous solubility. Prepare stock solutions fresh where possible, aliquot to avoid repeated freeze-thaw cycles, and store at -20 °C under inert atmosphere. Always verify the actual concentration by UV-Vis or HPLC analysis, and consult the CoA for lot-specific solubility data.
What are the potential research applications of this compound?
6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine belongs to the 2-aminothiazole privileged scaffold class widely explored in medicinal chemistry for kinase inhibitor design, antimicrobial research, and as intermediates in the synthesis of more complex heterocyclic drug candidates. Its combination of a pyridyl group and diamine functionality also makes it suitable as a ligand in coordination chemistry or as a building block for library synthesis.
How do I obtain a Certificate of Analysis (CoA) for SKU M732089?
Certificates of Analysis for M732089 are available from Aladdin Scientific by quoting the product SKU and the specific lot number printed on your product packaging. You can request the CoA through the Aladdin Scientific website product page or by contacting customer service. The CoA will include purity data and relevant analytical results for the specific batch supplied.
Are there any special regulatory or shipping considerations for this compound?
Shipping requirements depend on the hazard classification of the compound as determined by the applicable SDS and local transport regulations. Customers should review the Aladdin Scientific SDS for M732089 and ensure compliance with institutional, national, and international regulations for the transport and use of research chemicals. Contact Aladdin Scientific customer service for specific shipping and export documentation queries.
References
- Aladdin Scientific product page: 6-Methyl-N1-(4-(pyridin-3-yl)thiazol-2-yl)benzene-1,3-diamine, SKU M732089.
- Meyers M.J. et al. 2-Aminothiazoles as privileged scaffolds in medicinal chemistry: a review. (General textbook-level reference; specific citation not supplied in source material.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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