Animal model of atherosclerosis is a model that is artificially manipulated to produce atherosclerotic manifestations in animals. Currently, there are three methods for making animal models of atherosclerosis: diet-induced method, vascular endothelial injury method, and immunization method.

Principle

The basic principle of the diet-induced method is through the animal feed, plus excessive cholesterol and fat, feeding for a certain period of time, the emergence of hyperlipidemia, its aorta and coronary arteries can gradually form atherosclerotic plaques.

The basic principle of vascular endothelial damage method is to cause arterial endothelial damage or dysfunction through external forces, and then auxiliary feeding high-fat animal feed, plus excessive cholesterol and fat, feeding for a certain period of time.

The basic principle of the immunization method is to establish an animal model of atherosclerosis by stimulating an immune response triggered by bacteria and viruses leading to vascular endothelial injury.

Appliance

Animal models of atherosclerosis can be used to study the mechanisms of restenosis as well as preventive therapy.

Operation method

immunization

Principle

The basic principle of the immunoassay is to establish an animal model of atherosclerosis by stimulating an immune response triggered by bacteria and viruses leading to endothelial damage in blood vessels.

Materials and Instruments

Feed: High cholesterol feed
Animal: Rabbit

Move

The experimental steps for replicating the atherosclerosis animal model by the endothelial injury method are as follows:
A, Rabbits were given horse serum 1 oml/kg four times at 17-day intervals, and the rate of endothelial injury in the arteries was 88%.
B, Coronary arteries with atherosclerotic lesions developed, and the lesions were more pronounced when high cholesterol diets were given at the same time.

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