Cafestol (C274912 98%) and Kahweol (K274796 97%) are naturally occurring diterpenes present in coffee beans. These compounds and their derivatives demonstrate a wide range of biological activities, including chemopreventive, antioxidative, anti-angiogenic, and anticancer effects.

Epidemiological studies show that regular consumption of unfiltered coffee is linked to a decreased incidence of colon cancer. In animal models of colon carcinogenesis, Cafestol Palmitate (C274886 98%) and Kahweol Palmitate reduce the formation of DNA adducts induced by the carcinogen PhIP. This protective effect may stem from their ability to enhance the expression of glutathione-S-transferase, a phase II detoxification enzyme.

Both cafestol and kahweol exhibit anti-angiogenic and anti-inflammatory actions across several angiogenesis models. They inhibit tube formation as well as endothelial cell migration, invasion, and proliferation. Kahweol specifically suppresses the expression of pro-inflammatory mediators such as COX-2 and MCP-1.

Additionally, kahweol interferes with the differentiation of bone marrow–derived macrophages and monocytes into osteoclasts. By preventing osteoclast formation, it helps protect against bone resorption, thereby supporting bone strength and structural integrity.

Also available

K274797 Kahweol acetate 98%

Reference

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