What Is Cyclohexanesulfonamide?

Cyclohexanesulfonamide is an organosulfur compound belonging to the sulfonamide class, characterized by a cyclohexyl group attached to a –SO₂NH₂ moiety. Sulfonamides are well-established functional groups in synthetic and medicinal chemistry, known for their ability to participate in hydrogen bonding, coordinate with metal centers, and serve as bioisosteres for carboxylic acids and other acidic groups.

The compound is a white to off-white crystalline solid at room temperature. Its alicyclic cyclohexane scaffold imparts conformational rigidity compared to linear alkanesulfonamides, making it a useful structural motif when a defined three-dimensional shape is required in a target molecule.

Key Physicochemical Properties

Understanding the physicochemical profile of Cyclohexanesulfonamide is essential for selecting appropriate reaction conditions, solvents, and storage protocols. The key properties are summarized below based on textbook-level knowledge of sulfonamide chemistry:

• Molecular Formula: C₆H₁₃NO₂S
• Molecular Weight: 163.24 g/mol
• Appearance: White to off-white crystalline solid
• Solubility: Sulfonamides of this class are generally soluble in polar aprotic solvents such as DMSO and DMF, moderately soluble in alcohols, and sparingly soluble in water and non-polar organic solvents.
• Stability: Stable under normal laboratory conditions when stored in a cool, dry place away from strong oxidizing agents and strong acids or bases.

Researchers should consult the certificate of analysis (CoA) and safety data sheet (SDS) provided by Aladdin Scientific for lot-specific purity data and confirmed physical constants.

Laboratory Applications and Research Uses

Cyclohexanesulfonamide finds application across several areas of chemical research:

1. Organic Synthesis Building Block: The –SO₂NH₂ group can be N-alkylated, N-acylated, or engaged in condensation reactions to generate a diverse library of sulfonamide derivatives. The cyclohexyl ring provides a lipophilic, conformationally restricted scaffold that is valued in structure–activity relationship (SAR) studies.
2. Medicinal Chemistry: Cyclohexyl-bearing sulfonamides appear as motifs in biologically active compounds and drug candidates. The compound can serve as a starting material or reference standard when designing or characterizing novel sulfonamide-based therapeutics.
3. Coordination Chemistry: Sulfonamide NH protons can act as hydrogen-bond donors and the oxygen atoms as acceptors, enabling the formation of supramolecular assemblies or metal-organic frameworks under appropriate conditions.
4. Analytical Reference Standard: High-purity Cyclohexanesulfonamide is suitable for use as a reference standard in HPLC method development and validation when analyzing sulfonamide-containing samples.

Handling, Safety, and Storage

As with all laboratory reagents, appropriate precautions should be observed when handling Cyclohexanesulfonamide:

• Personal Protective Equipment (PPE): Wear appropriate gloves, laboratory coat, and eye protection. Avoid inhalation of dust.
• Storage: Store in a tightly sealed container in a cool, dry, well-ventilated area. Keep away from incompatible materials including strong oxidizers, strong acids, and strong bases.
• Disposal: Dispose of in accordance with local, regional, and national regulations applicable to chemical waste.
• SDS: Always consult the current Safety Data Sheet provided by Aladdin Scientific (available on the product page for SKU C192266) before use for comprehensive hazard and first-aid information.

Specific GHS hazard classifications and first-aid measures for this compound should be confirmed from the official Aladdin Scientific SDS, as hazard data may vary by regulatory jurisdiction and lot.

Ordering Cyclohexanesulfonamide from Aladdin Scientific

Cyclohexanesulfonamide is available from Aladdin Scientific under SKU C192266. To place an order or request a quotation:

• Search for SKU C192266 directly on the Aladdin Scientific website.
• Select the required pack size and quantity, then add to cart or submit a request for quotation (RFQ).
• For bulk quantities, custom packing, or institutional purchasing arrangements, contact the Aladdin Scientific sales team directly.
• A Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are available for download from the product page.

Aladdin Scientific ships research reagents globally; please refer to the shipping and delivery policy on the website for estimated lead times and cold-chain options relevant to your region.