Diallyl Trisulfide
Diallyl Trisulfide
Diallyl trisulfide (DATS) is an organosulfur compound derived from garlic and other Allium species. It is a decomposition product of allicin formed when garlic is crushed.
Figure 1. Chemical Structure of Diallyl Trisulfide
1. Bioactivity of Diallyl Trisulfide (DATS)
DATS exhibits antibacterial activity, inhibiting the growth of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.
In diabetic animal models, DATS improves cardiac function by enhancing the PI3K–Akt signaling pathway, inhibiting death receptor- and mitochondria-dependent apoptosis, thereby alleviating diabetic cardiomyopathy.
DATS possesses anticancer activity, with antioxidant properties potentially contributing to its chemotherapeutic effects. In leukemia cells, DATS promotes ROS generation, activates caspases, induces apoptosis, and suppresses proliferation.
DATS also exhibits chemopreventive effects. In a skin tumor carcinogenesis animal model, DATS inhibits TPA-induced papilloma formation and the increase in papilloma number.
2.Related Products
Name | ID | Specification/Purity |
Diallyl trisulfide | ≥65% | |
Allicin | ≥80%, mixture | |
Allicin | 10mM in DMSO | |
Diallyl Sulfide | ≥98% | |
L-Deoxyalliin | 10mM in Water | |
L-Deoxyalliin | ≥98%(T) | |
L-Alliin | ≥98% | |
(+)-Alliin | 10mM in DMSO | |
| (+)-Alliin | Analytical Standard, ≥98% | |
(+)-Alliin | ≥90% |
References
1. Casella S, Leonardi M, Melai B, et al. Phytother Res. 2013 Mar;27(3):380-3.
2. Huang YT, Yao CH, Way CL, et al. J Appl Physiol (1985). 2013 Feb;114(3):402-10.
3. Choi YH, Park HS. J Biomed Sci. 2012 May 11;19:50.
4. Kelkel M, Cerella C, Mack F, et al. Carcinogenesis. 2012 Nov;33(11):2162-71.v
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