What Is DRF-1042?

DRF-1042 is a selective inhibitor of DYRK1B (Dual-specificity tyrosine-regulated kinase 1B), a serine/threonine kinase belonging to the DYRK family of proteins. DYRK1B is frequently overexpressed in certain cancers, including pancreatic, ovarian, and lung cancers, where it plays a key role in promoting cell survival, driving quiescence, and enabling resistance to cytotoxic therapies.

Available from Aladdin Scientific under SKU D655919, DRF-1042 is catalogued under the cross-reference code MCE HY-125331 and is intended for in vitro and preclinical research use only.

Mechanism of Action

DRF-1042 exerts its effects by selectively binding to the ATP-binding pocket of DYRK1B, thereby inhibiting its kinase activity. DYRK1B phosphorylates multiple downstream substrates involved in cell-cycle regulation, including components of the Hedgehog signaling pathway and proteins that regulate G0/G1 arrest.

By blocking DYRK1B activity, DRF-1042 is hypothesized to disrupt tumor cell quiescence and sensitize cancer cells to chemotherapeutic agents. This dual role — modulating both proliferation and survival pathways — makes DRF-1042 a valuable pharmacological tool for dissecting DYRK1B biology in disease-relevant models.

Research Applications

DRF-1042 is primarily used as a chemical probe to investigate the role of DYRK1B in:

• Cancer cell quiescence: Studying how tumor cells enter and maintain dormant, therapy-resistant states.
• Combination therapy studies: Evaluating whether DYRK1B inhibition can sensitize resistant cancer cell lines to standard chemotherapeutics.
• Hedgehog pathway research: Probing DYRK1B's contributions to downstream Hedgehog signaling in pancreatic and other solid tumors.
• Kinase biology: Assessing selectivity profiles against related DYRK and CLK family members in biochemical panels.

Researchers are advised to validate solubility and stability conditions empirically for each specific assay format, as performance may vary with cell type, media composition, and experimental duration.

Handling, Storage, and Safety

As with all research-grade small molecules, DRF-1042 should be handled by trained laboratory personnel following institutional safety guidelines. General recommendations include:

• Storage: Store at –20 °C in a tightly sealed container, protected from light and moisture. Confirm specific storage conditions on the product datasheet.
• Solubility: Prepare stock solutions in DMSO; the exact solubility value should be verified experimentally or confirmed from the current product datasheet.
• Handling: Wear appropriate PPE (gloves, lab coat, eye protection). Avoid inhalation of powder or aerosols.
• Regulatory: For research use only (RUO). Not intended for diagnostic, therapeutic, or veterinary use.

Always consult the Safety Data Sheet (SDS) and the current Certificate of Analysis (CoA) available from Aladdin Scientific before use.

Ordering Information

DRF-1042 is available from Aladdin Scientific under the following details:

• SKU: D655919
• Cross-Reference: MCE HY-125331
• Supplier: Aladdin Scientific

For quantity pricing, bulk orders, or technical support, contact Aladdin Scientific customer service. Current pricing, available pack sizes, and stock status are listed on the product page. Orders may be placed online or through your institutional procurement channel.