Eprosartan Mesylate (SKF-108566J): Properties & Lab Use FAQ
Eprosartan Mesylate (SKF-108566J): Properties & Lab Use FAQ
Eprosartan Mesylate(SKF-108566J) is a selective, non-peptide angiotensin II type 1 (AT1) receptor antagonist widely used as a pharmacological research tool in cardiovascular and hypertension studies.
- Product Name
- Eprosartan Mesylate (SKF-108566J)
- Aladdin SKU
- E421622
- Target
- Angiotensin II AT1 Receptor
- Compound Class
- Non-peptide Angiotensin II Receptor Blocker (ARB)
- Primary Research Application
- Cardiovascular pharmacology, hypertension models
- Reference SKU
- E129480
What Is Eprosartan Mesylate (SKF-108566J)?
Eprosartan Mesylate, also known by its research code SKF-108566J, is the methanesulfonate salt form of Eprosartan. It belongs to the angiotensin II receptor blocker (ARB) class of compounds and acts as a selective antagonist at the AT1 receptor subtype. By blocking AT1 receptors, it inhibits angiotensin II-mediated vasoconstriction, aldosterone release, and sympathetic nervous system activation, making it a valuable tool compound for studying the renin-angiotensin-aldosterone system (RAAS) in vitro and in vivo.
In research settings, Eprosartan Mesylate is used to dissect the roles of AT1 versus AT2 receptor signaling, to establish hypertensive animal models, and to investigate cardioprotective mechanisms. The mesylate salt form is commonly employed to improve solubility relative to the free acid form.
Solubility, Formulation, and Storage Guidelines
Eprosartan Mesylate is generally soluble in water and DMSO at moderate concentrations suitable for cell-based assays and in vivo dosing. For aqueous formulations, researchers typically prepare stock solutions in sterile water or physiological saline. When higher concentrations are required, dissolution in DMSO followed by dilution into aqueous buffer is a common approach; ensure the final DMSO concentration does not exceed levels toxic to cells (typically ≤0.1% v/v for most cell lines).
Stock solutions should be stored at −20 °C in tightly sealed, light-protected vials to prevent degradation. Repeated freeze-thaw cycles should be avoided; single-use aliquots are recommended. The dry powder should be stored under inert atmosphere at low temperature as indicated on the product certificate of analysis. Always refer to the specific lot's Certificate of Analysis (CoA) for confirmed solubility data and purity.
Experimental Applications in Cardiovascular Research
Eprosartan Mesylate is employed across a range of in vitro and in vivo experimental paradigms. In cell-based assays, it is used to block AT1 receptor signaling in vascular smooth muscle cells, cardiomyocytes, and endothelial cells, enabling researchers to probe downstream pathways including ERK1/2 phosphorylation, NF-κB activation, and reactive oxygen species (ROS) generation triggered by angiotensin II.
In animal models, it is administered to rodents to study hypertension, cardiac hypertrophy, renal fibrosis, and stroke. Its selectivity for AT1 over AT2 receptors allows researchers to design experiments that attribute physiological and pathological effects specifically to AT1-mediated signaling. Additionally, Eprosartan Mesylate has been explored in neuroprotection studies given the expression of AT1 receptors in the central nervous system.
Ordering, Specifications, and Quality Information
Eprosartan Mesylate (SKF-108566J) is available from Aladdin Scientific under SKU E421622. A related reference product is listed under SKU E129480. When placing an order, researchers should confirm the required quantity, purity grade, and any special handling requirements with the Aladdin sales or technical support team.
Each lot is supplied with a Certificate of Analysis (CoA) confirming identity (typically by NMR or HPLC), purity, and appearance. Researchers should review the CoA before use and verify that the purity meets the requirements of their assay. For questions about bulk quantities, custom synthesis, or regulatory documentation such as MSDS/SDS, contact Aladdin customer service.
Frequently asked questions
What is the mechanism of action of Eprosartan Mesylate (SKF-108566J)?
Eprosartan Mesylate selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from binding and thereby inhibiting its vasoconstrictive, aldosterone-stimulating, and sympathomimetic effects. This blockade is competitive and reversible at the receptor level. It does not antagonize AT2 receptors at pharmacologically relevant concentrations, making it useful for dissecting AT1-specific signaling pathways.
In which solvents is Eprosartan Mesylate soluble, and how should stock solutions be prepared?
Eprosartan Mesylate is generally soluble in water and DMSO. For aqueous applications, stock solutions can be prepared in sterile water or saline. When higher concentrations are needed, dissolve in DMSO first and then dilute into the aqueous buffer, keeping the final DMSO content below cytotoxic levels. Always verify solubility data on the lot-specific Certificate of Analysis provided by Aladdin.
What are the recommended storage conditions for Eprosartan Mesylate (SKF-108566J)?
The dry powder should be stored at low temperature under an inert atmosphere, protected from light and moisture, as specified on the product CoA. Prepared stock solutions should be stored at −20 °C in single-use aliquots to avoid repeated freeze-thaw cycles, which can lead to compound degradation. Always seal vials tightly after use.
How does Eprosartan differ from other ARBs such as losartan or valsartan in a research context?
Eprosartan has a unique structural feature compared to most ARBs: it also inhibits presynaptic AT1 receptors on sympathetic nerve terminals, thereby reducing norepinephrine release in addition to its direct vascular AT1 blockade. This dual mechanism may make it particularly relevant for studies involving sympathetic nervous system modulation. Researchers should consider this additional pharmacological property when designing experiments.
What is the Aladdin SKU for Eprosartan Mesylate and is there a related reference product?
Eprosartan Mesylate (SKF-108566J) is listed under Aladdin SKU E421622. A related reference product is available under SKU E129480, as noted in the product description. For detailed specifications, availability, and pricing, contact Aladdin Scientific directly or visit the product page.
References
- Aladdin Scientific Product Page: Eprosartan Mesylate (SKF-108566J), SKU E421622. Reference: E129480.
- Brenner BM, et al. Angiotensin II receptor blockade and renal protection. General pharmacology of AT1 receptor antagonists. (Textbook-level reference — specific citation to be confirmed.)
- Oparil S, Eprosartan: a review of pharmacology and clinical use in hypertension. (Specific publication details not confirmed from source material.)
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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