Ethyl 2-(2-Methyl-4-nitro-1H-imidazol-1-yl)acetate FAQ
Ethyl 2-(2-Methyl-4-nitro-1H-imidazol-1-yl)acetate FAQ
Ethyl 2-(2-methyl-4-nitro-1h-imidazol-1-yl)acetate is a nitroimidazole-based heterocyclic ester building block used in organic synthesis and pharmaceutical research, available from Aladdin Scientific under SKU E768298.
- Product Name
- Ethyl 2-(2-methyl-4-nitro-1h-imidazol-1-yl)acetate
- SKU
- E768298
- Chemical Class
- Nitroimidazole ester derivative
- Core Structure
- 2-methyl-4-nitroimidazole ring N-alkylated with an ethyl acetate group
- Supplier
- Aladdin Scientific
- Recommended Storage
- Cool, dry, well-ventilated location; away from light and moisture (verify SDS for exact conditions)
Chemical Identity and Structure
Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate (SKU E768298) is a synthetic organic compound belonging to the nitroimidazole family. Its structure consists of a 2-methylimidazole ring bearing a nitro group at the 4-position, with an ethyl acetate moiety attached to the ring nitrogen (N-1). The combination of the electron-withdrawing nitro group and the ester functionality makes this compound a versatile intermediate in medicinal chemistry and heterocyclic synthesis.
The nitroimidazole scaffold is well recognized in pharmaceutical contexts, as related compounds are associated with antimicrobial and antiparasitic pharmacophores. The ester group provides a handle for further chemical elaboration, including hydrolysis, amide coupling, or reduction reactions.
Handling, Safety, and Storage
As with all nitro-containing organic compounds, Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate should be handled with appropriate laboratory precautions. Personnel should wear suitable personal protective equipment (PPE), including gloves, safety glasses, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood.
Store the compound in a cool, dry, and well-ventilated location, protected from light and moisture. Consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for authoritative hazard classification, first-aid measures, and disposal guidance before use. Specific GHS hazard categories and storage temperature requirements should be verified from the product SDS.
Applications in Research and Synthesis
Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate serves primarily as a synthetic building block in organic and medicinal chemistry. The N-alkylated nitroimidazole core can be elaborated into more complex structures relevant to drug discovery programs targeting anaerobic bacteria and parasitic protozoa, areas where nitroimidazole derivatives have demonstrated historical utility.
The ethyl ester group allows straightforward transformation: saponification yields the corresponding carboxylic acid, which can then be coupled with amines to produce amide derivatives; reduction of the nitro group provides access to amino-imidazole analogues. Researchers in heterocyclic chemistry may also employ this compound as a starting material for cyclization and ring-extension strategies.
Ordering and Procurement from Aladdin Scientific
Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate is available from Aladdin Scientific under SKU E768298. Researchers and procurement personnel can place orders directly through the Aladdin Scientific website or by contacting the sales team. For quotations on bulk quantities or custom packaging, please reach out to Aladdin Scientific customer support.
It is noted that an equivalent product may be listed under a comparable reference at partner suppliers (e.g., McLean reagents reference E939215). When ordering, always confirm the CAS number, purity specification, and pack size to ensure the material meets your experimental requirements. Certificate of Analysis (CoA) documents are available upon request.
Frequently asked questions
What is the chemical structure of Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate?
The compound features a 2-methylimidazole ring with a nitro substituent at the 4-position; the ring nitrogen (N-1) is alkylated with a –CH2–CO2Et (ethyl acetate) group. This N-substituted nitroimidazole ester architecture is characteristic of a versatile heterocyclic building block used in medicinal chemistry.
How should Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate be stored?
The compound should be stored in a cool, dry, well-ventilated area away from light and moisture. For precise storage temperature, humidity limits, and incompatibility information, always consult the official Safety Data Sheet (SDS) provided by Aladdin Scientific for SKU E768298.
What are the typical research applications of this nitroimidazole ester compound?
Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate is used primarily as a synthetic intermediate in organic and medicinal chemistry. Key applications include elaboration into nitroimidazole-based drug candidates, synthesis of amide or acid derivatives via ester hydrolysis and coupling, and preparation of amino-imidazole analogues through nitro group reduction.
How do I order Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate from Aladdin Scientific?
You can order this compound directly from the Aladdin Scientific website using SKU E768298. For bulk quantities, custom pack sizes, or institutional purchase orders, please contact Aladdin Scientific's sales or customer service team. A Certificate of Analysis (CoA) is available upon request.
Is Ethyl 2-(2-methyl-4-nitro-1H-imidazol-1-yl)acetate the same as McLean reagent E939215?
The source material notes that McLean (麦克林) reference E939215 corresponds to this compound. However, researchers should independently verify the CAS number, purity specification, and analytical data from the respective supplier's CoA before assuming equivalence for critical experiments.
References
- Aladdin Scientific product listing: Ethyl 2-(2-methyl-4-nitro-1h-imidazol-1-yl)acetate, SKU E768298.
- McLean reagent catalog reference E939215 (麦克林 E939215), noted as equivalent compound in source material.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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