Iron deficient anemia (iron deficient unemia) is an anemia that occurs when the stored iron available in the body for the production of hemoglobin has been depleted, and it is the most common type of anemia, especially in women of childbearing age and infants. This experiment is from Mudanjiang Medical College undergraduate 5-year laboratory guide for testing majors.

Operation method

Experimental analysis of the bone marrow picture in iron-deficiency anemia

Principle

Iron deficient anemia (iron deficient unemia) is an anemia that occurs when the stored iron available in the body for the production of hemoglobin has been depleted, and is the most common type of anemia, especially in women of childbearing age and infants.

Move

1. Causes of iron deficiency:

(1) Inadequate intake

(2) Poor absorption of iron

(3) Increased iron requirements

(4) Excessive iron loss

2. Consequences of iron deficiency: Iron deficiency has a serious effect on hemoglobin synthesis, causing microcytic hypochromic anemia.

Blood picture: the degree of anemia varies. Light for normal cells positive pigmentation, the severe is typical small cell hypochromic MCV60-80fl MCH15-2lpg. MCHC18-25% blood smear on the size of the red blood cells vary, the majority of small, elliptical red blood cells increased, and occasionally see target-shaped red blood cells. Erythrocyte staining is lighter, the center of the light stained area to expand the heavy only see the edge of the cytoplasm of a circle of red, ring-shaped, reticulocytes are generally normal, there are slightly more or slightly lower. The white blood cell count is normal, the iron deficiency anemia caused by hookworm disease has increased eosinophils.

Bone marrow image: myeloproliferative activity, significant proliferation of the red lineage. The granulocyte-red ratio decreases, and there is no obvious balance between the degree of bone marrow hyperplasia and the degree of anemia. Middle and late erythrocytes are more numerous, with smaller cytosol, smaller nucleus, darker chromatin, reduced cytoplasmic volume, grayish, grayish-blue or bluish color, with irregular margins, and no specific changes in the granulocyte and megakaryocyte lineages. Iron staining showed disappearance of extracellular iron and marked reduction or disappearance of intracellular iron (iron granules).

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