The experimental method was obtained from the official website of the Fourth Military Medical University

Operation method

Gavage experiments in rabbits and dogs

Materials and Instruments

Rabbit Dog
Dilators Catheters

Move

Monkeys, dogs, cats, rabbits For gavage, the animal is first immobilized and a special mouth dilator is placed in the animal's mouth and secured to the mouth with a string. A rubber catheter with elasticity (e.g., catheter) is inserted through the small round hole on the mouth expander and along the posterior wall of the pharynx and into the esophagus. At this time should check whether the catheter is inserted into the esophagus, the catheter can be placed in the outer mouth of a beaker of water, such as does not occur bubbles, that is, this catheter is considered to be in the esophagus, you can be instilled into the liquid. After completion of the gavage, the catheter is first removed, and then the mouth opener is removed (Fig. 1, Fig. 2)



Figure 1



Figure 2

The maximum volume that can be tolerated in a single gavage in various animals varies according to body weight: 0.5-1.0 ml in mice, 3-7 ml in rats, 4-6 ml in guinea pigs, 80-150 ml in rabbits, and 200-500 ml in dogs.

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