What Is iMDK and How Does It Work?

iMDK is a small-molecule compound reported to inhibit MDMX (also called MDM4), a key negative regulator of the tumor suppressor protein p53. By disrupting the MDMX–p53 interaction, iMDK is thought to relieve suppression of p53, allowing downstream transcriptional activation of pro-apoptotic and cell-cycle-arrest genes. Unlike MDM2-targeted agents, iMDK is described in the literature as showing selectivity toward MDMX, making it a useful tool compound for dissecting the distinct roles of MDM2 and MDMX in p53 regulation.

Note: Mechanistic details should be confirmed against the primary literature; see review flags below.

Key Applications in Research

iMDK is used primarily as a research tool compound in oncology and cell biology laboratories. Reported applications include:

• p53 pathway studies: Activating wild-type p53 signaling to study downstream transcriptional targets.
• Cancer cell line assays: Evaluating apoptosis, cell viability, and cell-cycle effects in tumor cell lines that retain wild-type p53.
• Mechanistic dissection: Comparing MDMX-selective inhibition versus MDM2 inhibition to clarify the relative contributions of each negative regulator.

iMDK is intended for in vitro research use only and is not approved for clinical, diagnostic, or veterinary applications.

Handling, Solubility & Storage Guidelines

Proper handling of iMDK is essential to maintain compound integrity and assay reproducibility:

• Solubility: Small-molecule MDMX inhibitors of this class are typically soluble in DMSO. Confirm solubility and working concentration in the product datasheet before use.
• Stock preparation: Prepare stock solutions in dry DMSO, aliquot to minimize freeze-thaw cycles, and store tightly sealed.
• Storage: Follow the specific conditions stated on the Aladdin Scientific product datasheet (generally −20 °C, protected from light and moisture).
• Working solutions: Dilute stock into aqueous assay buffer or cell culture media immediately before use; ensure final DMSO concentration does not exceed levels tolerated by your cell system (typically ≤0.1 %).

Always consult the current Certificate of Analysis (CoA) and Safety Data Sheet (SDS) supplied with your shipment.

Ordering iMDK from Aladdin Scientific

iMDK is available from Aladdin Scientific under SKU I648515. To order:

1. Search for SKU I648515 on the Aladdin Scientific website or contact your regional sales representative.
2. Confirm available pack sizes, current pricing, and lead times at the time of purchase, as these may vary.
3. For institutional or bulk orders, request a formal quotation through the Aladdin Scientific procurement portal or by email.
4. Upon receipt, inspect the shipment, verify the CoA, and store the compound according to label instructions.

For questions about payment, shipping, returns, or promotions, please refer to the relevant Help & Customer Service sections on the Aladdin Scientific website.