Hepatic drug enzymes is an abbreviation for the mixed function enzyme system of liver microsomes. This enzyme system is a group of mixed-function oxidative enzyme systems on the smooth endoplasmic reticulum that primarily catalyze many oxidative processes of structurally distinct drugs. The most important of these is CYP450, the cytochrome P450 monooxygenase system.CYP450 is a superfamily of a class of heme-thiolate proteins, which are involved in the metabolism of both endogenous and exogenous substances, including drugs and environmental compounds. Other related enzymes and coenzymes include NADPHCYP450 reductase, cytochrome b5, phosphatidylcholine, and NADPH. Many drugs or other compounds can alter the activity of hepatic enzymes, and those that do so are called "pharmacoenzyme inducers" and those that do not are called "pharmacoenzyme inhibitors".

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