Blood picture: total blood cell reduction is the typical blood picture manifestation of this disease, anemia progressively aggravates, hemoglobin can be less than 20g/L in severe cases, reticulocyte count is normal or high, white blood cell count varies in the early stage, and there is a decrease in the middle and late stage, even less than 1.0×109/L, platelets are reduced in most of them, and in a few cases, intermediate and late juvenile granulocytes are seen in the classification of leukocytes and can be found in the tail of the smear in some cases. Abnormal histiocytes and atypical monocytes can be found in the tail of the smear in some cases. Concentration of leukocyte smear can increase the detection rate of abnormal histiocytes, and the alkaline phosphatase staining positivity and points of neutrophils are significantly lower than normal or completely positive, and a few cases can have the blood picture of histiocytic or monocytic leukemia in the late stage. This experiment is from Mudanjiang Medical College, undergraduate 5-year laboratory guide for laboratory tests.

Operation method

Malignant Histiocytosis Detection Test

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Blood picture: total blood cell reduction is the typical blood picture manifestation of this disease, anemia progressively aggravates, hemoglobin can be less than 20g/L in severe cases, reticulocyte count is normal or high, white blood cell count varies in the early stage, and there is a decrease in the middle and late stage, even less than 1. ^0×109/L, platelets are reduced in most of them, and in a few cases, intermediate and late juvenile granulocytes are seen in the classification of leukocytes and can be found in the tail of the smear in some cases. Abnormal histiocytes and atypical monocytes can be found in the tail of the smear in some cases. Concentration of leukocyte smear can increase the detection rate of abnormal histiocytes, and the alkaline phosphatase staining positivity and points of neutrophils are significantly lower than normal or completely positive, and a few cases can have histiocytotic or monocytic leukemia in the late stage of the blood picture.

Bone marrow picture: most of the normal hematopoietic cells of various lineages can still be seen in the bone marrow smear, in which abnormal histiocytes can be seen, which is the most important feature of this disease. These cells are scattered or piled up in varying numbers. Because of the uneven distribution of the lesions, multiple bone marrow aspiration can increase the positive detection rate. According to the morphological characteristics of malignant histiocytes, they can be divided into five types: abnormal histiocytes, multinucleated giant cells, lymphoid histiocytes, mononucleated histiocytes, and phagocytosis-like histiocytes.

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