What Is Methyl 1H-Pyrazole-4-carboxylate Hydrochloride?

Methyl 1H-pyrazole-4-carboxylate hydrochloride (Aladdin SKU: M734566) is the hydrochloride salt form of methyl pyrazole-4-carboxylate, a five-membered nitrogen-containing heterocyclic compound. The pyrazole ring system bears a methyl ester substituent at the 4-position, and conversion to the hydrochloride salt improves the solid-state stability and handleability of the compound compared with the free base.

As a member of the pyrazole family, this compound serves as a key scaffold in drug discovery programs, where the pyrazole motif is frequently found in anti-inflammatory, antifungal, and kinase-inhibitor drug candidates. It is also employed as a versatile intermediate in the preparation of more complex heterocyclic architectures via N-alkylation, ester hydrolysis, amide coupling, or further functionalization of the ring system.

Handling, Safety, and Storage Guidelines

As with all laboratory reagents, appropriate personal protective equipment (PPE) — including nitrile gloves, safety spectacles, and a laboratory coat — should be worn when handling Methyl 1H-pyrazole-4-carboxylate hydrochloride. Work should be performed in a well-ventilated fume hood to avoid inhalation of dust or aerosols.

The hydrochloride salt form is generally more hygroscopic than the free base; therefore, containers should be resealed promptly after use and stored in a cool, dry environment. Long-term storage under inert atmosphere (nitrogen or argon) may help maintain compound integrity. Refer to the product Safety Data Sheet (SDS) provided by Aladdin Scientific for full hazard classification, first-aid measures, and disposal guidance before use.

Typical Applications in Synthetic Chemistry

Methyl 1H-pyrazole-4-carboxylate hydrochloride finds broad utility as a synthetic building block in several key reaction classes:

• N-Alkylation and N-Arylation: The NH of the pyrazole ring can be selectively alkylated or arylated under basic conditions to introduce diversity at the nitrogen positions, enabling the construction of N-substituted pyrazole libraries.
• Ester Hydrolysis and Amide Coupling: The methyl ester can be saponified to the corresponding carboxylic acid, which is then amenable to standard amide bond formation (e.g., using HATU, EDC/HOBt) to yield pyrazole-4-carboxamide derivatives relevant to medicinal chemistry programs.
• Metal-Catalyzed Cross-Coupling: After appropriate functionalization of the ring, the compound can participate in Suzuki–Miyaura, Buchwald–Hartwig, or other palladium-catalyzed transformations.
• Agrochemical Synthesis: Pyrazole-4-carboxylate esters are recognized pharmacophores in fungicide development, making this compound a useful intermediate for agrochemical research.

Ordering, Purity, and Quality Assurance

Methyl 1H-pyrazole-4-carboxylate hydrochloride is available from Aladdin Scientific under catalog number M734566. Researchers should consult the current product page or contact Aladdin's technical support team for up-to-date information on available pack sizes, purity specifications (typically confirmed by NMR, HPLC, and/or elemental analysis), lot-specific Certificates of Analysis (CoA), and current pricing.

For bulk or custom quantities, Aladdin Scientific's custom synthesis and bulk supply services may be able to accommodate project-specific requirements. Procurement teams should reference the SKU M734566 in all purchase orders to ensure accurate fulfillment.