N-(1H-1,2,4-Triazol-3-yl)acetamide: Properties & Lab FAQs
N-(1H-1,2,4-Triazol-3-yl)acetamide: Properties & Lab FAQs
N-(1H-1,2,4-Triazol-3-yl)acetamide is a nitrogen-rich heterocyclic amide compound featuring a 1,2,4-triazole ring system, valued in synthetic chemistry and pharmaceutical research as a versatile building block and bioactive scaffold.
- IUPAC Name
- N-(1H-1,2,4-triazol-3-yl)acetamide
- Core Scaffold
- 1,2,4-Triazole heterocycle with an acetamide substituent at the 3-position
- Molecular Formula
- C4H6N4O
- Key Functional Groups
- Triazole ring (N-H), amide carbonyl (C=O), secondary amine (N-H)
- Aladdin SKU
- N696979
- Typical Application
- Pharmaceutical intermediate, agrochemical research, coordination chemistry ligand precursor
Overview of N-(1H-1,2,4-Triazol-3-yl)acetamide
N-(1H-1,2,4-Triazol-3-yl)acetamide (SKU: N696979) is a small organic molecule comprising a 1,2,4-triazole ring coupled to an acetamide group at the 3-position of the ring. The 1,2,4-triazole scaffold is a five-membered aromatic heterocycle containing three nitrogen atoms, conferring the molecule with significant hydrogen-bond donor and acceptor capacity, as well as metabolic stability. These properties make triazole-based compounds highly attractive in medicinal chemistry, coordination chemistry, and materials science.
The acetamide moiety further extends the molecule's potential for intermolecular interactions, including hydrogen bonding and metal coordination, making N-(1H-1,2,4-Triazol-3-yl)acetamide a useful building block for the synthesis of more complex pharmacophores and functional materials.
Physicochemical Properties and Solubility
N-(1H-1,2,4-Triazol-3-yl)acetamide has the molecular formula C4H6N4O, giving a molecular weight of approximately 126.12 g/mol. The compound is a solid at room temperature. Its multiple nitrogen atoms and the amide carbonyl group contribute to strong intermolecular hydrogen bonding, which typically results in moderate-to-good solubility in polar protic solvents such as water, methanol, and dimethyl sulfoxide (DMSO).
For preparation of stock solutions, DMSO is generally preferred in biological assay contexts due to its excellent solvating power and compatibility with most assay systems at low concentrations. Aqueous solubility is expected to be reasonable owing to the polar nature of the molecule; however, researchers should verify solubility experimentally under their specific conditions before use.
Storage, Stability, and Handling Guidelines
As with most solid organic reagents containing amide and triazole functionalities, N-(1H-1,2,4-Triazol-3-yl)acetamide should be stored in a tightly sealed container, away from moisture and direct light, at room temperature or under refrigeration (2–8 °C) unless otherwise specified by the product datasheet. Proper desiccation is recommended to prevent hydrolysis of the amide bond under prolonged humid conditions.
Standard laboratory personal protective equipment (PPE) — including nitrile gloves, safety glasses, and a laboratory coat — should be worn when handling this compound. Researchers should consult the Safety Data Sheet (SDS) available from Aladdin Scientific for complete hazard information before use. Avoid inhalation of dust and contact with skin and eyes.
Applications in Research
The 1,2,4-triazole nucleus is one of the most pharmacologically privileged heterocycles, appearing in numerous approved drugs and agrochemicals. N-(1H-1,2,4-Triazol-3-yl)acetamide serves as a reactive intermediate or precursor in the synthesis of triazole-containing pharmaceuticals, including potential antifungal, antimicrobial, anti-inflammatory, and anticancer agents.
In coordination chemistry, the triazole nitrogen atoms act as effective ligands for transition metals, enabling the construction of metal-organic frameworks (MOFs) and coordination polymers with tunable properties. The acetamide group can also participate in further functionalization reactions, such as hydrolysis to yield the free amine (3-amino-1H-1,2,4-triazole) or condensation reactions to form more elaborate heterocyclic systems.
Ordering and Product Quality at Aladdin Scientific
N-(1H-1,2,4-Triazol-3-yl)acetamide is available from Aladdin Scientific under SKU N696979. Aladdin Scientific supplies research-grade reagents with associated quality documentation, including purity data typically determined by techniques such as HPLC or NMR. Researchers and procurement teams can place orders directly through the Aladdin Scientific website or by contacting the sales team.
For bulk quantities, custom synthesis inquiries, or specific purity and certification requirements (e.g., certificate of analysis, MSDS), please contact Aladdin Scientific customer service. Shipping, payment, and return policies are detailed on the Aladdin Scientific website and apply to all reagent orders.
Frequently asked questions
What is the molecular formula and molecular weight of N-(1H-1,2,4-Triazol-3-yl)acetamide?
The molecular formula of N-(1H-1,2,4-Triazol-3-yl)acetamide is C4H6N4O, corresponding to a molecular weight of approximately 126.12 g/mol. The compound consists of a five-membered 1,2,4-triazole ring with an acetamide group at the 3-position.
What solvents are recommended for dissolving N-(1H-1,2,4-Triazol-3-yl)acetamide?
DMSO and water are generally recommended as primary solvents for this polar, hydrogen-bonding compound; methanol is also a suitable option. For biological applications, DMSO stock solutions are commonly used and diluted into aqueous buffers. Researchers are advised to confirm solubility experimentally at the required concentration prior to use.
What are the recommended storage conditions for N-(1H-1,2,4-Triazol-3-yl)acetamide (SKU N696979)?
The compound should be stored in a tightly sealed container, protected from moisture and light, at room temperature or 2–8 °C with desiccation. Always refer to the Aladdin Scientific Certificate of Analysis and Safety Data Sheet supplied with the product for the most current and specific storage recommendations.
What are the primary research applications of N-(1H-1,2,4-Triazol-3-yl)acetamide?
This compound is primarily used as a building block or intermediate in medicinal chemistry for the synthesis of triazole-containing pharmacophores with potential antifungal, antimicrobial, anti-inflammatory, or anticancer activity. It also finds application in coordination chemistry as a ligand precursor for metal-organic frameworks and coordination polymers, as well as in agrochemical research.
How can I place an order for N-(1H-1,2,4-Triazol-3-yl)acetamide from Aladdin Scientific?
N-(1H-1,2,4-Triazol-3-yl)acetamide is available under SKU N696979 on the Aladdin Scientific website, where you can add the product to your cart, complete checkout, and select your preferred payment and shipping options. For bulk orders, special purity grades, or custom requirements, please contact Aladdin Scientific customer service directly.
References
- Comprehensive reviews on 1,2,4-triazole pharmacology and synthesis: general textbook-level knowledge on triazole heterocycles as pharmacophores and ligands.
- Aladdin Scientific product page for N-(1H-1,2,4-Triazol-3-yl)acetamide, SKU N696979.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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