Chemical Identity and Structure

N-(3-Amino-4-methylphenyl)-3-(trifluoromethyl)benzamide (SKU N726078) is a bifunctional benzamide compound. Its molecular formula is C₁₅H₁₃F₃N₂O, with a molecular weight of approximately 298.27 g/mol. The molecule features a 3-(trifluoromethyl)benzoyl group linked via an amide bond to the nitrogen of a 3-amino-4-methylaniline moiety.

The coexistence of a free primary aromatic amine at the 3-position and an amide nitrogen, together with the electron-withdrawing trifluoromethyl group and the electron-donating methyl substituent, endows this compound with versatile reactivity. The –CF₃ group confers increased lipophilicity, metabolic stability, and altered pKa relative to non-fluorinated analogues, properties that are highly valued in medicinal chemistry and agrochemical research.

The compound is expected to appear as a solid at room temperature; specific melting point and solubility data should be confirmed against the certificate of analysis supplied with each lot.

Handling and Storage Recommendations

Personal Protective Equipment (PPE): When handling this compound, wear appropriate PPE including nitrile gloves, a laboratory coat, and safety goggles. Aromatic amines as a chemical class may pose sensitization or toxicity risks; avoid inhalation of dust and direct skin contact.

Storage: Store the reagent in a tightly sealed container in a cool, dry, well-ventilated location, away from strong oxidizing agents and strong acids. Refrigerated storage (2–8 °C) is recommended to maintain long-term stability unless otherwise specified on the product label or certificate of analysis. Keep the container sealed when not in use to prevent moisture uptake and oxidation of the amine functionality.

Solubility: The compound is expected to show solubility in common polar aprotic solvents such as DMSO and DMF. Solubility in aqueous media will be limited due to the hydrophobic trifluoromethyl group. Verify solubility empirically for your specific experimental conditions.

Waste Disposal: Dispose of all waste in accordance with local institutional and governmental regulations governing halogenated organic compounds.

Research Applications

This compound serves primarily as a synthetic intermediate in medicinal chemistry, combinatorial chemistry, and materials science programs. Its key utility arises from the free primary amine group, which can be readily functionalized via:

• Acylation reactions to introduce additional amide or carbamate linkages
• Reductive amination to form secondary and tertiary amines
• Diazotization followed by coupling reactions for azo dye or heterocycle synthesis
• Condensation with carbonyl compounds to form imines or related derivatives

The preformed amide bond and the –CF₃ group make this scaffold particularly relevant for the preparation of candidate molecules in drug discovery programs targeting enzymes or receptors where fluorinated pharmacophores are desirable. The compound may also find use in agrochemical lead optimization and as a building block for fluorinated polymer research.

Note: Specific biological activity data for this compound are not confirmed in the available source material. Researchers should conduct their own literature review and experimental validation.

Quality and Ordering Information

N-(3-Amino-4-methylphenyl)-3-(trifluoromethyl)benzamide is available from Aladdin Scientific under SKU N726078. Each shipment is accompanied by a Certificate of Analysis (CoA) confirming identity, purity, and lot-specific physicochemical data. Researchers are advised to verify the CoA values — including purity by HPLC or NMR, appearance, and moisture content — before committing the material to sensitive synthetic steps.

For procurement inquiries, volume pricing, or custom packaging requests, contact Aladdin Scientific's technical sales team. Ensure that procurement records include the full IUPAC name, CAS number, and SKU to avoid ordering errors with structurally related analogues.

Storage conditions and shelf life are specified on the product label; adhere strictly to these to maintain reagent integrity throughout the product's working lifetime.