Chemical Identity and Structural Features

N-Methyl-3-phenyl-3-(2-(trifluoromethyl)phenoxy)propan-1-amine (SKU: N1225792) belongs to the class of 3-aryl-3-(aryloxy)propan-1-amines, a structural family that has attracted considerable attention in medicinal chemistry. The molecule comprises three principal structural elements: a phenyl group at the 3-position of the propylamine chain, a 2-(trifluoromethyl)phenoxy group connected via an ether oxygen, and a terminal N-methylamino group.

The trifluoromethyl (CF₃) substituent on the phenoxy ring is a well-established pharmacophoric element that modulates lipophilicity, metabolic stability, and membrane permeability relative to non-fluorinated analogs. The CF₃ group is strongly electron-withdrawing and imparts distinctive physicochemical properties, including increased log P and resistance to oxidative metabolism at the substituted aromatic position.

The secondary amine (N-methyl) terminus is a basic nitrogen center capable of salt formation, hydrogen-bond donation, and interaction with biological targets. Researchers should be aware that secondary amines may be susceptible to oxidation under ambient conditions; appropriate storage under inert atmosphere is therefore advisable.

Handling, Storage, and Safety Guidelines

Storage: Store N-Methyl-3-phenyl-3-(2-(trifluoromethyl)phenoxy)propan-1-amine in a tightly sealed container, protected from light, moisture, and heat. A dry, cool environment (typically 2–8 °C or as specified on the product label) under an inert atmosphere (nitrogen or argon) is recommended to prevent oxidation of the secondary amine and hydrolysis of the ether linkage. Always consult the product-specific Certificate of Analysis (CoA) for confirmed storage conditions.

Handling: Standard laboratory precautions for fine organic chemicals apply. Use appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and a laboratory coat. Manipulations producing dust or aerosols should be conducted in a well-ventilated fume hood. Avoid contact with skin, eyes, and mucous membranes. Wash hands thoroughly after handling.

Disposal: Dispose of this compound and all contaminated materials in accordance with local, regional, and national chemical waste regulations. Do not pour down the drain. Consult your institution's Environmental Health and Safety (EHS) office for guidance on disposal of fluorinated organic compounds.

Note: A full Safety Data Sheet (SDS) should be reviewed prior to use. Contact Aladdin Scientific customer support if an SDS is not available with your shipment.

Applications in Research and Organic Synthesis

The 3-aryl-3-(aryloxy)propan-1-amine scaffold is structurally related to pharmacologically active compounds investigated in the context of central nervous system (CNS) research. Researchers working in the area of monoamine reuptake inhibitor discovery or structure–activity relationship (SAR) studies may find this compound useful as a synthetic intermediate or reference standard.

In organic synthesis, N-Methyl-3-phenyl-3-(2-(trifluoromethyl)phenoxy)propan-1-amine can serve as a building block for the preparation of more complex fluorinated amines, amides, or quaternary ammonium salts. The secondary amine is amenable to acylation, sulfonylation, reductive amination, and alkylation reactions under standard conditions. The aryl ether linkage is generally stable to mild acidic and basic conditions but may be cleaved under strongly Lewis acidic or reducing conditions.

The presence of the CF₃ group makes this compound a useful tool for introducing fluorinated motifs into drug-like molecules, supporting efforts in lead optimization programs where metabolic stability or binding affinity improvements are sought.

Researchers are advised to conduct independent literature searches to identify the most current and relevant applications of this compound class in their specific field of study.

Quality, Purity, and Analytical Verification

Aladdin Scientific supplies N-Methyl-3-phenyl-3-(2-(trifluoromethyl)phenoxy)propan-1-amine (N1225792) as a research-grade reagent. Each lot is accompanied by a Certificate of Analysis (CoA) specifying purity, analytical methods employed, and lot-specific data. Researchers should request the CoA for their specific lot number prior to use in quantitative or pharmacological assays.

Recommended verification techniques for identity and purity confirmation include:

• NMR spectroscopy (¹H, ¹³C, and ¹⁹F NMR): The CF₃ group will produce a characteristic singlet in the ¹⁹F NMR spectrum. Proton NMR will reveal the N-methyl singlet and the characteristic benzylic CH proton.
• High-performance liquid chromatography (HPLC): Reverse-phase HPLC with UV detection is suitable for purity assessment.
• Mass spectrometry (MS): Electrospray ionization (ESI-MS) or APCI-MS is appropriate for molecular weight confirmation.
• Elemental analysis: May be used for absolute purity determination in demanding applications.

If analytical data do not match expected values, cease use and contact Aladdin Scientific customer support immediately.

Ordering and Customer Support

N-Methyl-3-phenyl-3-(2-(trifluoromethyl)phenoxy)propan-1-amine is available from Aladdin Scientific under SKU N1225792. To place an order, visit the Aladdin Scientific website, locate the product by SKU or name, and follow the standard ordering procedure. Bulk quantities or custom packaging may be available upon request; contact the sales team for a quotation.

For technical questions regarding this compound—including compatibility, analytical data, or application guidance—please contact Aladdin Scientific's technical support team. For order status, returns, or shipping inquiries, the customer service team is available through the website's support portal.

All purchases are subject to Aladdin Scientific's standard terms and conditions, including applicable pricing, payment, and return policies. Reward points or promotional discounts may apply; consult the promotions page on the website for current offers.