Acute primitive granulocytic leukemia (AML) is the most common type in adults, accounting for about 30.80% of acute leukemias, with an average of about 50%, and is divided into two subtypes according to the FAB and the opinion of our country's classification, i.e., for the undifferentiated type (M1) and the partially differentiated type (M2), and clinically, in addition to common manifestations of acute leukemias there are also the following features .....

This experiment was obtained from Mudanjiang Medical College Undergraduate 5-year laboratory guide for testing program

Operation method

Primitive granulocytic leukemia undifferentiated type experiment

Principle

Acute primitive myeloid leukemia (AML) is the most common type in adults, accounting for about 30.80% of acute leukemia, the average is about 50%, according to the FAB and China's classification of the opinion is divided into two subtypes, that is, for the undifferentiated (M1) and partially differentiated (M2), clinically in addition to the common manifestations of acute leukemia has the following characteristics: 1. most cases of the onset of disease is sudden, rapid progression, condition Most of the cases start suddenly, progress rapidly, and are often accompanied by severe infections, fever, hemorrhage, anemia, inflammation, ulceration or necrosis of the oral mucosa and the isthmus. 2. Enlargement of the liver, spleen, and lymph nodes is mild and less common than that of acute gonorrhea. 3. Green tumors are commonly found in acute granulomas, while acute mono, acute mono-mononuclear and acute gonorrhea are rare. 4.

Move

Hematology:

1. Anemia significant about 70% of patients Hb <6Og / L peripheral visible juvenile red blood cells.

2. Moderately elevated leukocyte count of 10-50×109/L is common.

3. Blood film is dominated by progranulocytes, which can account for 30-6O%, sometimes as high as 90% or more, and abnormal primitive granulocytes can be seen, but a few patients with non-leukemia have very few or no naïve granulocytes, and the small progranulocytes (cytosol is small and similar to the lymphocytes, cytosol is small, nucleus is rounded with fine granular chromatin, densely packed with more than the normal progranulocytes, and the nucleolus has 1-2 nucleoli). -2 nucleoli)

4. Platelets are moderately to severely reduced, below 50 x 109/L in half of the cases.

Bone marrow picture:

l. Bone marrow hyperplasia is extremely or markedly active, and in a few cases it may be hyperplastic or even diminished.

2. The majority of the bone marrow is composed of primitive granulocytes, with very few early granulocytes, and very few or no cells in the stages below mesophilic granulocytes.

3. Auer's vesicles are seen in a few cases of leukemia, and nuclear schistocytes are more common.

4. In most cases, there is a marked decrease in the number of young red blood cells and megakaryocytes, a severe decrease in platelets, and a relative decrease in lymphocytes.

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