Chemical Identity and Properties of Prometryn

Prometryn (CAS 7287-19-6) is a selective systemic herbicide belonging to the s-triazine chemical class. Its IUPAC name is N,N′-di-isopropyl-6-methylthio-1,3,5-triazine-2,4-diamine, and it carries the molecular formula C₁₀H₁₉N₅S with a molecular weight of approximately 241.36 g/mol. The compound acts primarily by inhibiting photosynthesis through blockade of electron transport at photosystem II in susceptible plants.

As a pure solid, prometryn appears as a white to off-white crystalline powder with a melting point in the range of 118–120 °C and relatively low water solubility (~33 mg/L at 20 °C), making it persistent in certain soil and aquatic environments. When dissolved in methanol at a precisely certified concentration, it forms a homogeneous, stable reference solution suitable for instrumental analysis. Methanol is the preferred solvent matrix for this standard because it is fully miscible with the mobile phases used in reverse-phase LC/MS and is compatible with GC injection systems after appropriate dilution.

Analytical Applications and Method Validation

Prometryn in Methanol is principally used as an external calibration standard and a spiking solution in the following analytical contexts:

• Pesticide residue analysis: Compliance testing of food commodities (cereals, vegetables, fruits) according to regulatory frameworks such as EU Regulation (EC) No 396/2005, US EPA pesticide tolerances, and GB 2763 in China requires traceable reference standards at known concentrations.
• Environmental monitoring: Surface water, groundwater, and soil extracts are routinely screened for triazine herbicides including prometryn under national and international monitoring programs.
• GC/MS and LC-MS/MS calibration: Multi-residue methods employ certified standard solutions to construct calibration curves, determine limits of detection (LOD) and quantification (LOQ), and assess matrix effects.
• Method development and validation: Laboratories developing new analytical methods per ICH Q2(R1), SANTE/11312/2021, or equivalent guidelines use certified standards to evaluate linearity, accuracy, precision, and recovery.

The certified concentration and associated uncertainty value printed on the Certificate of Analysis (CoA) enable direct traceability to SI units, satisfying ISO/IEC 17025 and ISO 17034 requirements for reference material use.

Preparation, Handling, and Storage

Handling precautions: Prometryn is classified as a herbicide with potential toxicity to non-target organisms. Methanol is a flammable solvent (flash point ~11 °C) classified as a Category 3 flammable liquid. Always handle this product in a well-ventilated fume hood, wear appropriate personal protective equipment (nitrile gloves, safety glasses, laboratory coat), and avoid inhalation of vapors. Consult the Safety Data Sheet (SDS) before use.

Storage: Store the sealed vial at 2–8 °C in a dedicated solvent-safe refrigerator, away from heat, open flames, and oxidizing agents. Keep the vial tightly capped when not in use to prevent evaporation of methanol, which would alter the certified concentration. Protect from light to prevent photodegradation of the active ingredient.

Preparation of working solutions: Use only volumetric glassware (Class A) and HPLC-grade or LC-MS-grade solvents when diluting this standard. Record the lot number, certified concentration, preparation date, and expiry date in your laboratory notebook or LIMS to maintain a full audit trail. Avoid freeze–thaw cycling; if aliquoting is required, transfer to amber glass vials and store under the same conditions.

Quality Assurance and Regulatory Compliance

Reference standards used in regulated testing laboratories must be fit for purpose and demonstrably traceable. Aladdin Scientific's Prometryn in Methanol (P301926) is supplied with a Certificate of Analysis detailing the certified concentration, purity, lot number, preparation date, and expiry date. Users should verify that the stated uncertainty meets their method's requirements before use.

For laboratories operating under Good Laboratory Practice (GLP), ISO/IEC 17025 accreditation, or food-safety regulatory mandates, the following documentation practices are recommended: (1) retain the original CoA as a controlled document; (2) log each use with date, analyst, and volume dispensed; (3) perform a system suitability check using the standard before each analytical sequence; and (4) compare results against independent quality-control (QC) samples to confirm calibration integrity.

When the stated expiry date is reached or if the solution shows visible particulates, discoloration, or concentration drift confirmed by QC checks, the standard must be discarded in accordance with local regulations for halogenated or nitrogen-containing organic solvent waste.

Ordering Information and Technical Support

Prometryn in Methanol is available from Aladdin Scientific under SKU P301926. When placing an order, please specify the required concentration and volume to ensure the correct product variant is supplied. Standard lead times apply; contact your regional Aladdin Scientific representative for availability, volume pricing, and custom concentration requests.

For technical inquiries regarding application suitability, method development assistance, or SDS requests, contact Aladdin Scientific's technical support team via the website or email. When contacting support, have the SKU, lot number, and a brief description of the analytical method available to expedite assistance.

Custom reference standards in alternative solvent matrices or at non-catalog concentrations may be available upon request; discuss specifications and minimum order quantities with a product specialist.