What Is RAB37 and Why Is It a Research Target?

RAB37 is a member of the RAB family of small monomeric GTPases, which are key regulators of intracellular vesicle trafficking, membrane fusion, and secretory pathways. RAB family proteins cycle between GTP-bound active and GDP-bound inactive states, thereby controlling cargo sorting and transport between organelles.

RAB37 has attracted growing research interest due to its reported roles in regulated secretion and its potential involvement in cancer biology, including modulation of metastasis-related pathways. Reliable, well-characterized antibodies such as RAB37 Mouse mAb (Ab351046) are essential tools for investigating RAB37 expression, localization, and function in these contexts.

Product Specifications and Formulation Details

RAB37 Mouse mAb (Ab351046) is produced using standard hybridoma technology with mouse as the host species, yielding a monoclonal antibody with high specificity for the RAB37 antigen. The product is supplied in PBS (phosphate-buffered saline) formulation without additional carrier proteins or preservatives unless otherwise stated on the Certificate of Analysis.

Key specifications include:

• Catalog Number: Ab351046
• Host: Mouse
• Antibody Class: Monoclonal
• Formulation: PBS only
• Reference Code: absea#KC-30581

Please consult the product datasheet or Certificate of Analysis for lot-specific details including concentration, immunogen information, and validated applications.

Recommended Applications and Usage Guidelines

Monoclonal antibodies against RAB37, such as Ab351046, are commonly evaluated for use in standard immunological techniques. Typical applications for anti-RAB GTPase monoclonal antibodies include:

• Western Blotting (WB): Detection of RAB37 protein in cell or tissue lysates under denaturing conditions.
• Immunofluorescence (IF): Visualization of RAB37 subcellular localization in fixed cells.
• Immunohistochemistry (IHC): Detection of RAB37 in formalin-fixed, paraffin-embedded (FFPE) tissue sections.
• Immunoprecipitation (IP): Pulldown of RAB37-containing complexes from cell lysates.

Note: Verified application data for Ab351046 should be confirmed on the product datasheet. Optimal working dilutions must be determined empirically for each application and sample type.

Storage, Handling, and Stability

Proper storage of RAB37 Mouse mAb (Ab351046) is critical to maintaining antibody activity and ensuring reproducible experimental results. General guidelines for PBS-formulated monoclonal antibodies include:

• Store at 2–8 °C for short-term use (up to 1 month).
• For long-term storage, aliquot and store at –20 °C to avoid repeated freeze-thaw cycles, which can degrade antibody performance.
• Avoid exposure to repeated freeze-thaw cycles; prepare single-use aliquots where possible.
• Keep away from direct light and microbial contamination.

Important: Always refer to the lot-specific datasheet and Certificate of Analysis supplied with the product for authoritative storage conditions, as formulations may vary between lots.

Ordering and Technical Support

RAB37 Mouse mAb is available from Aladdin Scientific under catalog number Ab351046. To place an order or request a quotation, visit the Aladdin Scientific website or contact your regional sales representative.

For technical inquiries — including application optimization, cross-reactivity questions, or lot-specific data requests — please contact Aladdin Scientific's technical support team with your catalog number (Ab351046) and experiment details. Our specialists can assist with protocol recommendations and troubleshooting to help you obtain optimal results.

Volume discounts and custom formulation options may be available; contact sales for details.