What Is NECAB2 and Why Is It a Research Target?

NECAB2 (N-terminal EF-hand Calcium-Binding Protein 2) is a member of the neuronal calcium sensor protein family. It contains EF-hand motifs that enable calcium ion binding, playing a role in intracellular calcium signaling pathways. NECAB2 is predominantly expressed in the nervous system and has been implicated in neuronal function, synaptic regulation, and potentially in neurological disease contexts. Its tissue-specific expression profile makes it a relevant target for neuroscience research, particularly in studies examining calcium-dependent signaling and neuronal physiology.

Note: Specific functional claims beyond textbook-level EF-hand calcium-binding protein biology should be verified against current primary literature. See review flags.

Product Specifications and Formulation Details

The Recombinant NECAB2 Antibody (Ab351129) from Aladdin Scientific is sourced under reference absea #RN-064. The antibody is formulated in PBS only, meaning it does not contain stabilizing carrier proteins such as BSA or preservatives such as sodium azide. This formulation is advantageous for applications where carrier proteins or preservatives could interfere with downstream assays, including conjugation experiments or highly sensitive detection methods.

Because the PBS-only formulation lacks preservatives, researchers should take particular care with storage and handling to maintain antibody integrity and activity over time.

Recommended Storage, Handling, and Stability

As this recombinant antibody is formulated in PBS without stabilizers or preservatives, proper storage is critical:

• Long-term storage: Store at -80°C for maximum stability.
• Short-term storage: -20°C is acceptable for shorter durations.
• Freeze-thaw cycles: Repeated freeze-thaw cycles should be avoided as they can lead to aggregation and loss of antibody activity. Consider preparing single-use aliquots upon receipt.
• Working aliquots: Keep at 4°C for up to one week if in active use; do not store at 4°C for extended periods without a preservative.

Specific stability data (e.g., shelf-life in months) are not provided in the current product documentation and should be confirmed with Aladdin Scientific technical support.

Ordering, Availability, and Customer Support

The Recombinant NECAB2 Antibody is available from Aladdin Scientific under catalog number Ab351129. To place an order or request a quotation, researchers and procurement teams may contact Aladdin Scientific through the official website or designated regional distributors.

For technical inquiries regarding validated applications, optimal working dilutions, or compatibility with specific assay platforms, please reach out to the Aladdin Scientific technical support team. Application-specific validation data (e.g., WB, IHC, IF, ELISA) should be confirmed directly with technical support, as the current product documentation does not enumerate validated applications explicitly.

Returns, refunds, and shipping queries should be directed to Aladdin Scientific customer service in accordance with the company's standard policies.