Red Clover Extract: Key Facts, Uses & FAQs
Red Clover Extract: Key Facts, Uses & FAQs
Red Clover Extract is a standardized botanical research reagent derived from Trifolium pratense, concentrated in bioactive isoflavone compounds widely studied for their phytoestrogenic and antioxidant properties.
- Product Name
- Red Clover Extract
- SKU
- R1449930
- Botanical Source
- Trifolium pratense (Red Clover)
- Primary Bioactives
- Isoflavones including formononetin, biochanin A, daidzein, and genistein
- Intended Use
- In vitro and in vivo research; not for human therapeutic use
- Reference Catalog Cross
- MCE-TJY: HY-N13216
What Is Red Clover Extract?
Red Clover Extract is a standardized plant-derived extract obtained from the aerial parts or flowers of Trifolium pratense L. (Fabaceae). The extract is characterized by its enriched content of isoflavone glycosides and aglycones, most notably formononetin, biochanin A, daidzein, and genistein. These polyphenolic compounds are classified as phytoestrogens due to their structural similarity to 17β-estradiol, enabling them to interact with estrogen receptors (ERα and ERβ) in cellular systems.
Aladdin Scientific offers Red Clover Extract (SKU: R1449930) as a research-grade reagent intended for laboratory use in pharmacological, biochemical, and cell biology studies. The product cross-references MCE-TJY catalog number HY-N13216.
Research Applications of Red Clover Extract
Red Clover Extract is employed across a broad range of biomedical research contexts. Key application areas include:
- Phytoestrogenic activity studies: Investigating ERα/ERβ binding affinity and downstream signaling of constituent isoflavones in hormone-responsive cell lines.
- Antioxidant research: Assessing free-radical scavenging capacity and oxidative-stress modulation in cellular and acellular assay systems.
- Bone metabolism research: Exploring isoflavone effects on osteoblast and osteoclast activity in models of bone density regulation.
- Cardiovascular research: Examining effects on lipid profiles and vascular endothelial function in relevant in vitro models.
- Anti-inflammatory studies: Evaluating modulation of pro-inflammatory cytokine pathways by red clover isoflavones.
All applications listed are for research purposes only and are not intended for diagnostic, therapeutic, or food-use applications.
Handling, Storage, and Safety Guidance
To maintain the integrity and potency of Red Clover Extract (R1449930), researchers should observe the following general best practices:
- Storage: Store in a cool, dry location away from direct light. Specific temperature conditions should be confirmed on the product datasheet or certificate of analysis supplied with each lot. Typical guidance for plant polyphenol extracts recommends storage at −20 °C when not in active use.
- Solubility: Red clover isoflavones are generally soluble in DMSO and ethanol. Aqueous solubility is limited; prepare stock solutions in an appropriate organic solvent and dilute into aqueous buffers immediately before use. Final DMSO concentrations in cell-based assays should be kept ≤0.1% to avoid solvent cytotoxicity.
- Handling: Use standard laboratory PPE (gloves, lab coat, safety glasses). Avoid inhalation of fine powder. Consult the Safety Data Sheet (SDS) for lot-specific hazard information.
- Stability: Minimize freeze-thaw cycles by preparing single-use aliquots. Protect solutions from oxidation by working under inert atmosphere when feasible.
Ordering and Quality Information
Red Clover Extract is available from Aladdin Scientific under SKU R1449930. Researchers and procurement teams can place orders through the Aladdin Scientific website or via their regional sales representative.
- Cross-reference: This product corresponds to MCE-TJY catalog number HY-N13216, facilitating straightforward sourcing for labs already familiar with that reference.
- Documentation: A Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are available upon request or downloadable from the product page. Lot-specific purity and characterization data are provided with each shipment.
- Quotations and bulk orders: Contact Aladdin Scientific customer service for volume pricing, custom pack sizes, or expedited shipping requirements.
- Returns and refunds: Please refer to Aladdin Scientific's standard returns and refund policy available on the website. Products must be assessed for suitability prior to use; claims should be submitted promptly upon receipt.
Frequently asked questions
What is the catalog number for Red Clover Extract at Aladdin Scientific?
Red Clover Extract is listed under SKU R1449930 at Aladdin Scientific. It also cross-references MCE-TJY catalog number HY-N13216, which can be used when comparing sourcing options across suppliers.
What are the main bioactive compounds in Red Clover Extract?
Red Clover Extract is primarily characterized by its isoflavone content, including formononetin, biochanin A, daidzein, and genistein. These phytoestrogenic compounds are the primary focus of most research applications involving this extract. Exact concentrations and standardization specifications should be confirmed on the lot-specific Certificate of Analysis.
How should Red Clover Extract be dissolved for cell-based assays?
Red clover isoflavones exhibit limited aqueous solubility and are best dissolved initially in DMSO or ethanol to prepare a concentrated stock solution. This stock should then be diluted into the aqueous assay medium immediately before use. Ensure the final DMSO concentration does not exceed 0.1% v/v in cell culture systems to minimize solvent-related cytotoxicity artifacts.
Is Red Clover Extract (R1449930) suitable for in vivo animal studies?
Red Clover Extract R1449930 is supplied as a research reagent and may be used in appropriately designed in vivo studies in accordance with institutional animal care guidelines. Researchers should verify purity specifications on the CoA and consult relevant literature for dosing and formulation guidance. This product is not intended for human use or clinical applications.
Where can I obtain the Safety Data Sheet (SDS) and Certificate of Analysis (CoA) for R1449930?
The SDS and CoA for Red Clover Extract (R1449930) are available through the Aladdin Scientific product page on the website, or can be requested directly from customer service. Lot-specific documentation is provided with each shipment and is also available upon request before purchase.
References
- Booth, N.L. et al. The chemical and biological profile of a red clover (Trifolium pratense L.) phase II clinical extract. Journal of Alternative and Complementary Medicine, 2006.
- Atkinson, C. et al. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial. Breast Cancer Research, 2004.
- Lipovac, M. et al. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Gynecological Endocrinology, 2012.
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
危险品化学品经营许可证（带存储）